ReviewThe International journal of artificial organs2016
Mechanical blood trauma in assisted circulation: sublethal RBC damage preceding hemolysis.
Review in The International journal of artificial organs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Application of an autotransfusion pressure control system in blood salvage.The Journal of international medical research · 2023Trial
- Mixed hemodiafiltration reduces erythropoiesis stimulating agents requirement in dialysis patients: a prospective randomized study.Journal of nephrology · 2020Trial
- Continuous LVAD monitoring reveals high suction rates in clinically stable outpatients.Artificial organs · 2020Trial
- Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.Computer methods and programs in biomedicine · 2025Article
- The Mechanical Properties of Erythrocytes Are Influenced by the Conformational State of Albumin.Cells · 2025Review
- Effect of intercellular collisions on red blood cell membrane damage.Scientific reports · 2025Article
- Mechanical Stimulation of Red Blood Cells Aging: Focusing on the Microfluidics Application.Micromachines · 2025Review
- The dynamics of red blood cells traversing slits of mechanical heart valves under high shear.Biophysical journal · 2024Article
- Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support.Journal of the American Heart Association · 2024Article
- Observational
- Optimization of a Screw Centrifugal Blood Pump Based on Random Forest and Multi-Objective Gray Wolf Optimization Algorithm.Micromachines · 2023Article
- Challenge of material haemocompatibility for microfluidic blood-contacting applications.Frontiers in bioengineering and biotechnology · 2023Review
- Acquired platelet defects are responsible for nonsurgical bleeding in left ventricular assist device recipients.Artificial organs · 2022Article
- The effect of blood viscosity on shear-induced hemolysis using a magnetically levitated shearing device.Artificial organs · 2022Article
- The application of del Nido cardioplegia for myocardial protection in adult coronary artery bypass grafting: a cohort study.Journal of thoracic disease · 2022Article
- Validation of a Miniaturized Test Loop for the Assessment of Human Blood Damage by Continuous-Flow Left-Ventricular Assist Devices.Annals of biomedical engineering · 2021Article
- Production of erythrocyte microparticles in a sub-hemolytic environment.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- Development and accuracy evaluation of a degree of occlusion visualization system for roller pumps used in cardiopulmonary bypass.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- The impact of circulation in a heart-lung machine on function and survival characteristics of red blood cells.Artificial organs · 2020Article
- Temperature and flow rate limit the optimal ex-vivo perfusion of the heart - an experimental study.Journal of cardiothoracic surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
After many decades of improvements in mechanical circulatory assist devices (CADs), blood damage remains a serious problem during support contributing to variety of adverse events, and consequently affecting patient survival and quality of life. The mechanisms of cumulative cell damage in continuous-flow blood pumps are still not fully understood despite numerous in vitro, in vivo, and in silico studies of blood trauma. Previous investigations have almost exclusively focused on lethal blood damage, namely hemolysis, which is typically negligible during normal operation of current generation CADs. The measurement of plasma free hemoglobin (plfHb) concentration to characterize hemolysis is straightforward, however sublethal trauma is more difficult to detect and quantify since no simple direct test exists. Similarly, while multiple studies have focused on thrombosis within blood pumps and accessories, sublethal blood trauma and its sequelae have yet to be adequately documented or characterized. This review summarizes the current understanding of sublethal trauma to red blood cells (RBCs) produced by exposure of blood to flow parameters and conditions similar to those within CADs. It also suggests potential strategies to reduce and/or prevent RBC sublethal damage in a clinically-relevant context, and encourages new research into this relatively uncharted territory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.