Evidence map›Paper›PMID 27034274›Full record

ArticleCirculation research2016

Duchenne Muscular Dystrophy Mice and Men: Can Understanding a Genetic Cardiomyopathy Inform Treatment of Other Myocardial Diseases?

Jill A Rafael-Fortney, Jessica A Chadwick, Subha V Raman

Abstract read
In one paragraph

Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. rAAVrh74.MCK.GALGT2 Protects against Loss of Hemodynamic Function in the Aging mdx Mouse Heart.Molecular therapy : the journal of the American Society of Gene Therapy · 2019
    Article
  10. Acute ATJournal of molecular and cellular cardiology · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jill A Rafael-FortneyFrom the Department of Physiology and Cell Biology (J.A.R.-F., J.A.C.), Division of Cardiovascular Medicine, Department of Internal Medicine (S.V.R.), College of Medicine and Wexner Medical Center, The Ohio State University, Columbus. rafael-fortney.1@osu.edu.
Jessica A ChadwickFrom the Department of Physiology and Cell Biology (J.A.R.-F., J.A.C.), Division of Cardiovascular Medicine, Department of Internal Medicine (S.V.R.), College of Medicine and Wexner Medical Center, The Ohio State University, Columbus.
Subha V RamanFrom the Department of Physiology and Cell Biology (J.A.R.-F., J.A.C.), Division of Cardiovascular Medicine, Department of Internal Medicine (S.V.R.), College of Medicine and Wexner Medical Center, The Ohio State University, Columbus.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular DystrophyR01HL116533 · NHLBI · OHIO STATE UNIVERSITY · PI RAFAEL-FORTNEY, JILL A, RAMAN, SUBHA V · 2013 to 2017
$2.7M
Mechanisms and synergies of therapeutic drug treatments in muscular dystrophyR01NS082868 · NINDS · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML, RAFAEL-FORTNEY, JILL A · 2013 to 2017
$1.7M
Training in neuromuscular diseasesT32NS077984 · NINDS · OHIO STATE UNIVERSITY · PI GUTTRIDGE, DENIS C, MENDELL, JERRY ROY · 2012 to 2016
$946k
NCATS NIH HHS UL1 TR000090NCATS NIH HHS UL1TR000090NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR001070NHLBI NIH HHS R01 HL116533NINDS NIH HHS R01 NS082868NINDS NIH HHS T32 NS077984
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCardiomyopathiesCardiomyopathy, DilatedCardiovascular AgentsClaudin-5Disease ProgressionDouble-Blind MethodDrug Evaluation, PreclinicalDystrophinGene Expression RegulationGenetic TherapyHeart FailureHumansMiceMice, Inbred mdxMineralocorticoid Receptor AntagonistsCardiovascular AgentsClaudin-5Cldn5 protein, mouseDMD protein, humanDystrophinMineralocorticoid Receptor AntagonistsUtrn protein, mouseUtrophincardiomyopathyclaudin-5dystrophinheartmineralocorticoid receptor

Identifiers

PMID27034274
PMCPMC4819164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.