ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2017
Factors affecting cartilage repair after medial opening-wedge high tibial osteotomy.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Arthroscopic evidence of improvement in cartilage lesions after medial opening-wedge high-tibial osteotomy with valgus correction and its positive impact on clinical outcomes, a prospective study.International orthopaedics · 2025Trial
- Clinical benefit of high tibial osteotomy combined with the intervention of platelet-rich plasma for severe knee osteoarthritis.Journal of orthopaedic surgery and research · 2022Trial
- Comparison of Clinical and Radiological Outcomes between Calibratable Patient-Specific Instrumentation and Conventional Operation for Medial Open-Wedge High Tibial Osteotomy: A Randomized Controlled Trial.BioMed research international · 2022Trial
- Structural Gains Without Symptomatic Benefit After Microfracture During High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- Relationships Among Bone Marrow Lesions, Cartilage Improvement, and Short- to Midterm Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- [Impact of lower limb weight bearing line ratio on motor function recovery after high tibial osteotomy].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Favorable 10-year outcomes of osteochondral autologous transplantation for spontaneous osteonecrosis of the knee following subchondral insufficiency fracture with optimal alignment correction.Knee surgery & related research · 2025Article
- High tibial osteotomy in geriatric patients with gonarthrosis.BMC geriatrics · 2025Article
- Treatment of osteoarthritic knee with high tibial osteotomy and allogeneic human umbilical cord blood-derived mesenchymal stem cells combined with hyaluronate hydrogel composite.Stem cell research & therapy · 2025Observational
- Effects of concurrent cartilage procedures on cartilage regeneration in high tibial osteotomy: a systematic review.Knee surgery & related research · 2024Review
- Osteotomy Correction Angle Cut-off Points Can Guide the Operation to Prevent a Significant Decrease in Patella Height.Orthopaedic surgery · 2024Article
- Allogeneic umbilical cord blood-derived mesenchymal stem cell implantation versus microdrilling combined with high tibial osteotomy for cartilage regeneration.Scientific reports · 2024Article
- Plate Hooking Transtibial Medial Meniscus Posterior Root Pull-Out Repair with Medial Open-Wedge High Tibial Osteotomy for Knee Osteoarthritis with Medial Meniscus Posterior Root Tear.Arthroscopy techniques · 2023Article
- Analysis of the determinant factor of the medial joint space width after medial opening wedge high tibial osteotomy.Archives of orthopaedic and trauma surgery · 2023Article
- Change in Cartilage Status of Medial Compartment after Open-Wedge High Tibial Osteotomy without Cartilage Regeneration Procedure: Second Look Arthroscopic Assessment.Biomedicines · 2023Article
- Long-Term Survival and Predictors of Failure of Opening Wedge High Tibial Osteotomy.Orthopaedic surgery · 2023Article
- Current practice of concomitant surgeries in cartilage repair of the femorotibial compartment of the knee: baseline data of 4968 consecutive patients from the German cartilage registry (KnorpelRegister DGOU).Archives of orthopaedic and trauma surgery · 2023Article
- Medial opening-wedge high tibial osteotomy with microfracture in treatment of varus medial compartmental knee osteoarthritis: clinical outcomes and second-look arthroscopic results.Frontiers in bioengineering and biotechnology · 2023Article
- Observational
- Restoration of the Knee Medial Collateral Ligament and Complete Soft-tissue Coverage After Medial Open-Wedge High Tibial Osteotomy.Arthroscopy techniques · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study documented the healing potential of degenerated articular cartilage after opening-wedge valgus high tibial osteotomy (HTO) in patients with osteoarthritis of the knee. It was hypothesized that regeneration of articular cartilage is affected by several factors, including preoperative cartilage degeneration grade, difference between the medial femoral condyle (MFC) and the medial tibial condyle (MTC), and postoperative knee alignment.
methodsMedial opening-wedge valgus HTO was performed in 131 knees of 100 patients (mean age 66 ± 7.7 years). Initial arthroscopy was performed at the time of HTO, and a second-look arthroscopy was performed at the time of plate removal (20.8 ± 6.5 months after HTO). Status of articular cartilage was assessed according to the ICRS grade. Cartilage regeneration was also evaluated by the presence of newly formed cartilaginous tissue. All subjects were followed up postoperatively at 2 years for assessment of clinical and radiographic outcomes.
resultsThe number of subjects in ICRS grade 1/2/3/4 was significantly altered from 0/11/53/67 preoperatively to 14/21/56/40 postoperatively in the MFC (P < 0.05) and 0/12/62/57 preoperatively to 9/24/64/34 postoperatively in the MTC (P < 0.05). Newly formed cartilaginous tissue was found in 71 % of MFCs and 51 % of MTCs. Incidence of cartilage regeneration was significantly higher in lower BMI cases, MFC, preoperatively advanced ICRS grade and overcorrected knees. Age, gender and clinical outcomes did not affect cartilage regeneration.
conclusionCartilage regeneration in degenerated articular cartilage is induced after opening-wedge valgus HTO, which is affected by BMI, the difference between the MFC and MTC, preoperative cartilage degeneration grade, and postoperative limb alignment. Therefore, patient selection by BMI rather than age, and surgical techniques maintaining valgus knee alignment should be considered for cartilage regeneration. LEVEL OF EVIDENCE: Level IV, therapeutic case series.
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