Evidence map›Paper›PMID 27033945›Full record

ReviewSurvey of ophthalmology

Optic disk drusen in children.

Melinda Y Chang, Stacy L Pineles

Open access · greenAbstract readReview
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Agreement and Accuracy of Papilledema and Pseudopapilledema Classification Among Pediatric Neuro-Ophthalmologists Using Optic Disc Photographs.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2025
    Observational
  6. Article
  7. Review
  8. Distinguishing Papilledema from Pseudopapilledema in Children.Advances in ophthalmology and optometry · 2024
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Evaluation of the signs and symptoms of pseudotumor cerebri syndrome in pediatric population.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  18. Multimodal Imaging Features of Optic Disc Drusen.American journal of ophthalmology · 2021
    Article
  19. Article
  20. Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melinda Y ChangDepartment of Ophthalmology, Stein Eye Institute, Los Angeles, California, USA; University of California, Stein Eye Institute, Los Angeles, California, USA.
Stacy L PinelesDepartment of Ophthalmology, Stein Eye Institute, Los Angeles, California, USA; University of California, Stein Eye Institute, Los Angeles, California, USA.
Southern California Eye Institute · US

Funding

Binocular Summation in StrabismusK23EY021762 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PINELES, STACY · 2011 to 2015
$1.1M
NEI NIH HHS K23 EY021762
6 · The paper itself

Abstract

Optic disk drusen occur in 0.4% of children and consist of acellular intracellular and extracellular deposits that often become calcified over time. They are typically buried early in life and generally become superficial, and therefore visible, later in childhood, at the average age of 12 years. Their main clinical significance lies in the ability of optic disk drusen, particularly when buried, to simulate true optic disk edema. Misdiagnosing drusen as true disk edema may lead to an invasive and unnecessary workup for elevated intracranial pressure. Ancillary testing, including ultrasonography, fluorescein angiography, fundus autofluorescence, and optical coherence tomography, may aid in the correct diagnosis of optic disk drusen. Complications of optic disk drusen in children include visual field defects, hemorrhages, choroidal neovascular membrane, nonarteritic anterior ischemic optic neuropathy, and retinal vascular occlusions. Treatment options for these complications include ocular hypotensive agents for visual field defects and intravitreal anti-vascular endothelial growth factor agents for choroidal neovascular membranes. In most cases, however, children with optic disk drusen can be managed by observation with serial examinations and visual field testing once true optic disk edema has been excluded.

Indexed as

Optic Disk DrusenVisual AcuityVisual FieldsChildFluorescein AngiographyFundus OculiGlobal HealthHumansIncidenceOptic DiskTomography, Optical Coherencechildrenchoroidal neovascular membraneoptic disk drusenpediatricpseudopapilledema

Identifiers

PMID27033945
PMCPMC5042815
OpenAlexW2335718878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.