ArticleScientific reports2016
Generation of cloned mice and nuclear transfer embryonic stem cell lines from urine-derived cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Resurrection of chromosomes from frozen animals by single chromosome transfer into mouse oocytes.Scientific reports · 2026Article
- Limitations of serial cloning in mammals.Nature communications · 2026Article
- The challenges and prospects of mammalian reproduction in extraterrestrial environments.The Journal of reproduction and development · 2026Review
- Can Humanity Thrive Beyond the Galaxy?The Journal of reproduction and development · 2025Review
- Mouse somatic cell nuclear transfer: What has changed and remained unchanged in 25 years.The Journal of reproduction and development · 2023Article
- Live births from urine derived cells.PloS one · 2023Article
- Healthy cloned offspring derived from freeze-dried somatic cells.Nature communications · 2022Article
- Evaluation of porcine urine-derived cells as nuclei donor for somatic cell nuclear transfer.Journal of veterinary science · 2022Article
- Tolerance of the freeze-dried mouse sperm nucleus to temperatures ranging from -196 °C to 150 °C.Scientific reports · 2019Article
- Generation of two-cell cloned embryos from mouse faecal cell.Scientific reports · 2018Article
- Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer.Journal of visualized experiments : JoVE · 2018Article
- Melatonin enhances the developmental competence of porcine somatic cell nuclear transfer embryos by preventing DNA damage induced by oxidative stress.Scientific reports · 2017Article
- Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Urine-Derived Stem Cells: The Present and the Future.Stem cells international · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cloning animals by nuclear transfer provides the opportunity to preserve endangered mammalian species. However, there are risks associated with the collection of donor cells from the body such as accidental injury to or death of the animal. Here, we report the production of cloned mice from urine-derived cells collected noninvasively. Most of the urine-derived cells survived and were available as donors for nuclear transfer without any pretreatment. After nuclear transfer, 38-77% of the reconstructed embryos developed to the morula/blastocyst, in which the cell numbers in the inner cell mass and trophectoderm were similar to those of controls. Male and female cloned mice were delivered from cloned embryos transferred to recipient females, and these cloned animals grew to adulthood and delivered pups naturally when mated with each other. The results suggest that these cloned mice had normal fertility. In additional experiments, 26 nuclear transfer embryonic stem cell lines were established from 108 cloned blastocysts derived from four mouse strains including inbreds and F1 hybrids with relatively high success rates. Thus, cells derived from urine, which can be collected noninvasively, may be used in the rescue of endangered mammalian species by using nuclear transfer without causing injury to the animal.
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