ArticleScientific reports2016
Age-specific percentile-based reference curve of serum procalcitonin concentrations in Japanese preterm infants.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs.Immunity, inflammation and disease · 2026Review
- Comparing procalcitonin and C-reactive protein levels in very low birth weight infants with sepsis.Pediatric research · 2026Article
- Imputation of missing clock times - application to procalcitonin concentration time course after birth.Journal of pharmacokinetics and pharmacodynamics · 2025Article
- Study of some biological markers in cord blood of preterm and term infants and their association with neonatal sepsis.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Diagnostic value of procalcitonin and hemocyte parameters in neonates with bloodstream infection: Role of activated hemocyte-related genes.Pediatric discovery · 2024Article
- Enhancing sepsis biomarker development: key considerations from public and private perspectives.Critical care (London, England) · 2024Review
- Procalcitonin-Based Antibiotic Use for Neonatal Early-Onset Bacterial Infections: Pre- and Post-Intervention Clinical Study.Antibiotics (Basel, Switzerland) · 2023Article
- Introducing heart rate variability monitoring combined with biomarker screening into a level IV NICU: a prospective implementation study.European journal of pediatrics · 2022Article
- Procalcitonin levels in preterm newborns: Reference ranges during the first three days of life.Frontiers in pediatrics · 2022Article
- Predictive Value of Ionized Calcium for Prognosis of Sepsis in Very Low Birth Weight Infants.Journal of inflammation research · 2022Article
- Early-onset sepsis risk calculator: a review of its effectiveness and comparative study with our evidence-based local guidelines.Italian journal of pediatrics · 2021Article
- Procalcitonin in Preterm Neonates: A Different Threshold and Prolonged Interpretation.Frontiers in pediatrics · 2021Article
- Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis.Children (Basel, Switzerland) · 2020Review
- Diagnostic Accuracy of Biomarkers for Early-Onset Neonatal Bacterial Infections: Evaluation of Serum Procalcitonin Reference Curves.Diagnostics (Basel, Switzerland) · 2020Article
- Expression of Pancreatic Stone Protein is Unaffected by Trauma and Subsequent Surgery in Burn Patients.World journal of surgery · 2020Article
- Utility of Procalcitonin as a Biomarker for Sepsis in Children.Journal of clinical microbiology · 2020Review
- [Diagnostic value of procalcitonin in neonatal early-onset sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- [Clinical value of blood lactate in predicting the prognosis of neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Procalcitonin versus C-reactive protein: review of kinetics and performance for diagnosis of neonatal sepsis.Journal of perinatology : official journal of the California Perinatal Association · 2019Review
- Is Procalcitonin Useful in Pediatric Critical Care Patients?Biomarker insights · 2018Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Procalcitonin (PCT) levels are elevated early after birth in newborn infants; however, the physiological features and reference of serum PCT concentrations have not been fully studied in preterm infants. The aims of the current study were to establish an age-specific percentile-based reference curve of serum PCT concentrations in preterm infants and determine the features. The PCT concentration peaked in infants at 1 day old and decreased thereafter. At 1 day old, serum PCT concentrations in preterm infants <34 weeks' gestational age were higher than those in late preterm infants between 34 and 36 weeks' gestational age or term infants ≥37 weeks' gestational age. Although the 50-percentile value in late preterm and term infants reached the adult normal level (0.1 ng/mL) at 5 days old, it did not in preterm infants. It took 9 weeks for preterm infants to reach it. Serum PCT concentrations at onset in late-onset infected preterm infants were over the 95-percentile value. We showed that the physiological feature in preterm infants was significantly different from that in late preterm infants, even in those <37 weeks' gestational age. To detect late-onset bacterial infection and sepsis, an age-specific percentile-based reference curve may be useful in preterm infants.
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