ArticlePhysiological reports2016
Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Morin Prevents Non-Alcoholic Hepatic Steatosis in Obese Rats by Targeting the Peroxisome Proliferator-Activated Receptor Alpha (PPARα).Life (Basel, Switzerland) · 2024Article
- Sex-Dependent T Cell Dysregulation in Mice with Diet-Induced Obesity.International journal of molecular sciences · 2024Article
- Article
- Age and Sex: Impact on adipose tissue metabolism and inflammation.Mechanisms of ageing and development · 2021Review
- Diet-induced obesity in animal models: points to consider and influence on metabolic markers.Diabetology & metabolic syndrome · 2021Review
- T cells accumulate in non-diabetic islets during ageing.Immunity & ageing : I & A · 2021Article
- Tauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2021Article
- Translational Modeling of Psychomotor Function in Normal and AD-Pathological Aging With Special Concerns on the Effects of Social Isolation.Frontiers in aging · 2021Article
- Blackcurrant (Nutrients · 2019Article
- The impact of age and sex on body composition and glucose sensitivity in C57BL/6J mice.Physiological reports · 2019Article
- Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.Scientific reports · 2018Article
- Age-Dependent Neurochemical Remodeling of Hypothalamic Astrocytes.Molecular neurobiology · 2018Article
- T Cells in Adipose Tissue in Aging.Frontiers in immunology · 2018Review
- Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes.Physiological reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In obesity, adipose tissue (AT) and liver are infiltrated with Th-1 polarized immune cells, which are proposed to play an important role in the pathogenesis of the metabolic abnormalities of obesity. Aging is also associated with increased adiposity, but the effects of this increase on inflammation and associated metabolic dysfunction are poorly understood. To address this issue, we assessed insulin resistance (IR) andATand liver immunophenotype in aged, lean (AL) and aged, obese (AO) mice, all of whom were maintained on a standard chow diet (11% fat diet) throughout their lives. For comparison, these variables were also assessed in young, lean (YL) and young diet-induced obese mice (41% fat diet,YO). Despite similar body weight and fat accumulation,YOmice were substantially moreIRand had greater liver steatosis compared toAOmice.YOalso had elevated infiltration of macrophages/dendritic cells inATand liver, but these increases were absent inAO Furthermore, liver immune cells ofYOwere more Th-1 polarized thenAO Notably, aging was associated with accumulation of T cells, but this occurred independent of obesity. Together, the data suggest that reduced inflammation inAOunderlies the improved insulin sensitivity and lowered steatosis compared toYO.
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Registered trials
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