Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Feasibility of shortened scan acquisition time with IQ-SPECT technology using SMARTZOOM(TM) collimator in myocardial perfusion imaging.Asia Oceania journal of nuclear medicine & biology · 2025Article
- Personalization ofEJNMMI physics · 2023Article
- Deep learning, another important tool for improving acquisition efficiency in SPECT MPI Imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Simulating dose reduction for myocardial perfusion SPECT using a Poisson resampling method.Nuclear medicine and molecular imaging · 2021Article
- Effect of reduced photon count levels and choice of normal data on semi-automated image assessment in cardiac SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Improving Diagnostic Accuracy in Low-Dose SPECT Myocardial Perfusion Imaging With Convolutional Denoising Networks.IEEE transactions on medical imaging · 2020Article
- Drivers of radiation dose reduction with myocardial perfusion imaging: A large health system experience.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Review
- Radiation dose in nuclear medicine: the hybrid imaging.La Radiologia medica · 2019Review
- Contemporary Cardiac SPECT Imaging-Innovations and Best Practices: An Information Statement from the American Society of Nuclear Cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Review
- New techniques, distinctive population, unique normal databases.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Creation and characterization of normal myocardial perfusion imaging databases using the IQ·SPECT system.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Using advanced technology to reduce the dose of SPECT MPI radiation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Myocardial perfusion scintigraphy dosimetry: optimal use of SPECT and SPECT/CT technologies in stress-first imaging protocol.Clinical and translational imaging · 2016Review
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent technological advances in myocardial perfusion imaging may warrant the use of lower injected activity. We evaluated whether quantitative measures of stress myocardial perfusion defects using Tc-99m sestamibi and low-energy high-resolution (LEHR) collimators are equivalent to lower dose SPECT-CT with cardiac multifocal collimators and software (IQ·SPECT).
methods93 patients underwent one-day rest-stress gated SPECT-CT. Following conventional rest imaging, 925-1100 MBq (25-30 mCi) of Tc-99m sestamibi was injected during stress testing. Stress SPECT-CT images were acquired two ways: with LEHR (13 minutes) and IQ·SPECT (7 minutes). Low-dose IQ·SPECT stress was simulated by subsampling the full-dose data to half-, quarter-, and eighth-count levels. Abnormalities were quantified using the total perfusion deficit (TPD) score and dose-specific databases.
resultsThe mean ± SD of the differences between LEHR and IQ·SPECT TPD scores were -1.01 ± 5.36%, -0.10 ± 5.81%, 1.78 ± 4.81%, and 1.75 ± 6.05% at full, half, quarter, and eighth doses, respectively. Differences were statistically significant for quarter and eighth doses. Correlation between LEHR and IQ·SPECT was excellent at all doses (R ≥ 0.93). Bland-Altman plots demonstrated minimal bias.
conclusionsWith IQ·SPECT, quantitative stress SPECT-CT imaging is possible with half of the standard injected activity in half the time.
Indexed as
Identifiers
27033352What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.