ArticleScientific reports2016
Serotonin modulates glutamatergic transmission to neurons in the lateral habenula.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.Neurobiology of stress · 2024Article
- Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine.Neuropharmacology · 2023Review
- The circadian clock in the mouse habenula is set by catecholamines.Cell and tissue research · 2022Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Activation of AMPA Receptors in the Lateral Habenula Produces Anxiolytic Effects in a Rat Model of Parkinson's Disease.Frontiers in pharmacology · 2022Article
- Stress induces divergent gene expression among lateral habenula efferent pathways.Neurobiology of stress · 2020Article
- The Emerging Role of LHb CaMKII in the Comorbidity of Depressive and Alcohol Use Disorders.International journal of molecular sciences · 2020Review
- Article
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula.International journal of molecular sciences · 2020Article
- Serotonin Type 6 and 7 Receptors as a Novel Therapeutic Target for the Treatment of Schizophrenia.Neuropsychiatric disease and treatment · 2020Review
- Activation of 5-HTBehavioural brain research · 2019Article
- Preferential modulation of the lateral habenula activity by serotonin-2A rather than -2C receptors: Electrophysiological and neuroanatomical evidence.CNS neuroscience & therapeutics · 2018Article
- A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling.Translational psychiatry · 2018Article
- Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving.Pharmacology, biochemistry, and behavior · 2017Review
- An emerging role for the lateral habenula in aggressive behavior.Pharmacology, biochemistry, and behavior · 2017Review
- The antidepressant bupropion is a negative allosteric modulator of serotonin type 3A receptors.Neuropharmacology · 2017Article
- Low-dose ethanol excites lateral habenula neurons projecting to VTA, RMTg, and raphe.International journal of physiology, pathophysiology and pharmacology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The lateral habenula (LHb) is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin receptors. However, actions of serotonin on the excitatory synaptic transmission to LHb neurons have not been thoroughly investigated. The LHb contains two anatomically and functionally distinct regions: lateral (LHbl) and medial (LHbm) divisions. We compared serotonin's effects on glutamatergic transmission across the LHb in rat brains. Serotonin bi-directionally and differentially modulated glutamatergic transmission. Serotonin inhibited glutamatergic transmission in higher percentage of LHbl neurons but potentiated in higher percentage of LHbm neurons. Magnitude of potentiation was greater in LHbm than in LHbl. Type 2 and 3 serotonin receptor antagonists attenuated serotonin's potentiation. The serotonin reuptake blocker, and the type 2 and 3 receptor agonists facilitated glutamatergic transmission in both LHbl and LHbm neurons. Thus, serotonin via activating its type 2, 3 receptors, increased glutamate release at nerve terminals in some LHb neurons. Our data demonstrated that serotonin affects both LHbm and LHbl. Serotonin might play an important role in processing information between the LHb and its downstream-targeted structures during decision-making. It may also contribute to a homeostatic balance underlying the neural circuitry between the LHb and raphe nuclei.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.