ArticleJournal of neuro-oncology2016
Executive dysfunction is associated with poorer health-related quality of life in pediatric brain tumor survivors.
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis of Executive Function Outcomes in Pediatric Central Nervous System Tumor Survivors.Actas espanolas de psiquiatria · 2026Pooled it
- Health-related quality of life in children and adolescents with paediatric acquired brain injury: Secondary data analysis from a randomised controlled trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- The feasibility and efficacy of short-term visual-motor training in pediatric posterior fossa tumor survivors.European journal of physical and rehabilitation medicine · 2022Trial
- Effect of Occupation Performance Coaching with Four-Quadrant Model of Facilitated Learning on Children with Specific Learning Disorder.Occupational therapy international · 2022Trial
- The Brainfit study: efficacy of cognitive training and exergaming in pediatric cancer survivors - a randomized controlled trial.BMC cancer · 2018Trial
- Navigating the challenges of moving from research to clinical care: The example of the Teen Online Problem Solving program.Journal of pediatric rehabilitation medicine · 2026Article
- Predicting neuropsychological late effects in pediatric brain tumor survivors using the Neurological Predictor Scale and the Pediatric Neuro-Oncology Rating of Treatment Intensity.Journal of the International Neuropsychological Society : JINS · 2024Article
- Long-term postoperative quality of life in childhood survivors with cerebellar mutism syndrome.Frontiers in psychology · 2023Article
- Review
- The impact of CNS-directed treatment on quality of life in childhood cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Sleep Disturbance and Its Association With Sluggish Cognitive Tempo and Attention in Pediatric Brain Tumor Survivors.Frontiers in neuroscience · 2022Article
- Impact of sleep, neuroendocrine, and executive function on health-related quality of life in young people with craniopharyngioma.Developmental medicine and child neurology · 2021Article
- Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.International journal of clinical oncology · 2020Article
- Self-reported and parent proxy reported functional impairment among pediatric cancer survivors and controls.Health and quality of life outcomes · 2020Article
- Stroke impact on mortality and psychologic morbidity within the Childhood Cancer Survivor Study.Cancer · 2020Article
- Guidelines for Treatment and Monitoring of Adult Survivors of Pediatric Brain Tumors.Current treatment options in oncology · 2019Review
- Normal tissue damage: its importance, history and challenges for the future.The British journal of radiology · 2019Review
- Review
- A prospective study of family predictors of health-related quality of life in pediatric brain tumor survivors.Pediatric blood & cancer · 2018Article
- Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma.Cancer · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Children with a brain tumor (BT) are at risk for a number of physical and cognitive problems that may lower their health-related quality of life (HRQoL). Executive functioning (EF) and intellectual ability are hypothesized to associate with HRQoL and deficits in these areas may be amenable to interventions. This study aimed to investigate intellectual function, EF, and HRQoL following conformal radiation therapy (CRT) for pediatric BT. Forty-five BT survivors (age 12.68 ± 2.56) treated with CRT participated. Thirty-six siblings of BT patients (age 12.36 ± 2.13) and 33 survivors of non-CNS solid tumors (ST; age 12.18 ± 2.88) were comparison groups. IQ estimate (Wechsler Abbreviated Scale of Intelligence; WASI), EF ratings (Behavior Rating Inventory of Executive Function; BRIEF), and HRQoL ratings (KINDL-R) were obtained. BT survivors reported lower overall HRQoL than ST survivors (p = .012). Parents reported lower overall HRQoL for BT survivors than siblings (p = .014). Parent-report on individual areas of HRQoL was higher than self-report for most subscales. IQ and HRQoL ratings were not related (Parent r = .17, p = .27; Child r = .11, p = .49). EF ratings correlated with Parent (r = -.15 to -.73) but not Child HRQoL ratings. Children with BT experienced poorer HRQoL than controls. Children's HRQoL was consistently rated higher by parent- than self-report across all domains. HRQoL was associated with EF, but not with IQ. These findings identify interventions targeting EF (e.g., cognitive rehabilitation, medication) as a possible avenue for improving HRQoL in childhood BT survivors.
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