Evidence map›Paper›PMID 27032981›Full record

ReviewNature reviews. Endocrinology2016

Micronutrient deficiencies in pregnancy worldwide: health effects and prevention.

Alison D Gernand, Kerry J Schulze, Christine P Stewart, Keith P West, Parul Christian

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 354 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed, 16 pooled it
33.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03394963 completednot on this mapstarted 2019, after this paper: background citation

Scientific Foundations for Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index for Ethiopia

TypeobservationalSponsorEthiopian Public Health InstituteRan2019 to 2022Enrolled500ConditionsHealthyArmsFood-based dietary guidelines for healthier diet
NCT03921177 naterminatednot on this mapstarted 2019, after this paper: background citation

Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5)

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2019 to 2021Enrolled9,859ConditionsBirth Weight, Miscarriage, Small-for-gestational Age, Preterm BirthArmsMultiple micronutrient supplement, Placebo Oral Tablet
3 · Its place in the literature

Who cites it

354 citing papers in PubMed, 16 syntheses or guidelines pooled it, 719 citations in OpenAlex.

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294 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alison D GernandDepartment of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Laboratory, University Park, Pennsylvania 16802, USA.
Kerry J SchulzeCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Christine P StewartDepartment of Nutrition, One Shields Avenue, University of California, Davis, California 95616, USA.
Keith P WestCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Parul ChristianCenter for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.
Johns Hopkins University · USPennsylvania State University · USUniversity of California, Davis · US

Funding

Career Development Program in Women's Health Research at Penn StateK12HD055882 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WEISMAN, CAROL S · 2007 to 2016
$4.7M
NICHD NIH HHS K12 HD055882NICHD NIH HHS K12HD055882
6 · The paper itself

Abstract

Micronutrients, vitamins and minerals accessible from the diet, are essential for biologic activity. Micronutrient status varies widely throughout pregnancy and across populations. Women in low-income countries often enter pregnancy malnourished, and the demands of gestation can exacerbate micronutrient deficiencies with health consequences for the fetus. Examples of efficacious single micronutrient interventions include folic acid to prevent neural tube defects, iodine to prevent cretinism, zinc to reduce risk of preterm birth, and iron to reduce the risk of low birth weight. Folic acid and vitamin D might also increase birth weight. While extensive mechanistic and association research links multiple antenatal micronutrients with plausible materno-fetal health advantages, hypothesized benefits have often been absent, minimal or unexpected in trials. These findings suggest a role for population context in determining health responses and filling extensive gaps in knowledge. Multiple micronutrient supplements reduce the risks of being born with low birth weight, small for gestational age or stillborn in undernourished settings, and justify micronutrient interventions with antenatal care. Measurable health effects of gestational micronutrient exposure might persist into childhood but few data exists on potential long-term benefits. In this Review, we discuss micronutrient intake recommendations, risks and consequences of deficiencies, and the effects of interventions with a particular emphasis on offspring.

Indexed as

AdultDietFemaleHumansMicronutrientsNutritional StatusPregnancyPregnancy ComplicationsPregnancy OutcomeMicronutrients

Identifiers

PMID27032981
PMCPMC4927329
OpenAlexW2325817714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.