ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Short-term aerobic exercise training improves gut peptide regulation in nonalcoholic fatty liver disease.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Impact of short-term exercise training intensity on β-cell function in older obese adults with prediabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults.Nutrients · 2018Trial
- Metabolic dysfunction-associated steatotic liver disease: pathogenic mechanisms and exercise-induced molecular adaptations.Lipids in health and disease · 2026Review
- Liraglutide combined with HIIT preserves contractile apparatus and blunts the progression of heart failure in diabetic cardiomyopathy rats.Scientific reports · 2025Article
- The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- The Effects of a Short-Term Combined Exercise Program on Liver Steatosis Indices and the Lipidemic and Glycemic Profile in NAFLD Individuals: A Pilot Study.Metabolites · 2023Article
- The role of exercise and hypoxia on glucose transport and regulation.European journal of applied physiology · 2023Review
- Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms.Nutrients · 2023Review
- An American Physiological Society cross-journal Call for Papers on "The Physiology of Obesity".American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Effect of Bariatric Surgery on Metabolic Diseases and Underlying Mechanisms.Biomolecules · 2021Review
- Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD).Nutrients · 2020Review
- Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD.Medicine and science in sports and exercise · 2020Article
- Non-invasive assessment of hepatic lipid subspecies matched with non-alcoholic fatty liver disease phenotype.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019Article
- Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Exercise and glucagon-like peptide-1: Does exercise potentiate the effect of treatment?World journal of diabetes · 2018Article
- Review
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
Obesity-related nonalcoholic fatty liver disease (NAFLD) is now the most common chronic liver disease. Exercise and diet are uniformly prescribed treatments for NAFLD; however, there are limited empirical data on the effects of exercise training on metabolic function in these patients. The purpose of this study was to investigate the fasting and glucose-stimulated adaptation of gut peptides to short-term aerobic exercise training in patients with NAFLD. Twenty-two obese subjects, 16 with NAFLD [body mass index (BMI), 33.2 ± 1.1 (SE) kg/m(2)] and 6 obese controls (BMI, 31.3 ± 1.2 kg/m(2)), were enrolled in a supervised aerobic exercise program (60 min/day, 85% of their heart rate maximum, for 7 days). Fasting and glucose-stimulated glucagon-like peptide-1 (GLP-17-36) and peptide tyrosine tyrosine (PYYTotal) concentrations in plasma were assessed before and after the exercise program. Initially, the NAFLD group had higher fasting PYY (NAFLD = 117 ± 18.6, control = 47.2 ± 6.4 pg/ml, P < 0.05) and GLP-1 (NAFLD = 12.4 ± 2.2, control = 6.2 ± 0.2 pg/ml, P < 0.05) and did not significantly increase GLP-1 or PYY in response to glucose ingestion. After the exercise program, fasting GLP-1 was reduced in the NAFLD group (10.7 ± 2.0 pg/ml, P < 0.05). Furthermore, exercise training led to significant increase in the acute (0-30 min) PYY and GLP-1 responses to glucose in the NAFLD group, while the total area under the glucose-stimulated GLP-1 response curve was reduced in both NAFLD and controls (P < 0.05). In summary, 7 days of vigorous aerobic exercise normalized the dynamic PYY and GLP-1 responses to nutrient stimulation and reduced the GLP-1 response in NAFLD, suggesting that exercise positively modulates gut hormone regulation in obese adults with NAFLD.
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