ReviewDrug discovery today2016
Protein crystallization screens developed at the MRC Laboratory of Molecular Biology.
Review in Drug discovery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab-binding domain.Protein science : a publication of the Protein Society · 2026Article
- Article
- The FUSION protein crystallization screen.Journal of applied crystallography · 2022Article
- Molecular mechanism of Mad1 kinetochore targeting by phosphorylated Bub1.EMBO reports · 2021Article
- A structural and kinetic survey of GH5_4 endoglucanases reveals determinants of broad substrate specificity and opportunities for biomass hydrolysis.The Journal of biological chemistry · 2020Article
- Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex.Nucleic acids research · 2020Article
- A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.Acta crystallographica. Section F, Structural biology communications · 2020Article
- Half Way to Hypusine-Structural Basis for Substrate Recognition by Human Deoxyhypusine Synthase.Biomolecules · 2020Article
- Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology.Journal of visualized experiments : JoVE · 2018Article
- Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092.Journal of visualized experiments : JoVE · 2017Article
- Computational Approaches for Revealing the Structure of Membrane Transporters: Case Study on Bilitranslocase.Computational and structural biotechnology journal · 2017Review
- Schema Matching and Data Integration with Consistent Naming on Protein Crystallization Screens.IEEE/ACM transactions on computational biology and bioinformaticsArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In order to solve increasingly challenging protein structures with crystallography, crystallization reagents and screen formulations are regularly investigated. Here, we briefly describe 96-condition screens developed at the MRC Laboratory of Molecular Biology: the LMB sparse matrix screen, Pi incomplete factorial screens, the MORPHEUS grid screens and the ANGSTROM optimization screen. In this short review, we also discuss the difficulties and advantages associated with the development of protein crystallization screens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.