ArticleMedical science monitor : international medical journal of experimental and clinical research2016
Effects of Silk Sericin on Incision Wound Healing in a Dorsal Skin Flap Wound Healing Rat Model.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 100 citations in OpenAlex.
- Silk sericin and its biomedical applications: extraction methods, genetic insights (Ser1-Ser6), and developments of multifunctional biomaterials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Biophysical properties and antimicrobial efficacy of a novel Silk Sericin Mineral Trioxide Aggregate.Frontiers in dental medicine · 2025Article
- Promoting of Biomechanics' Properties Incisional Wound Repair by Mesenchymal Stem Cell Transplantation.World journal of plastic surgery · 2025Article
- Eco-Friendly Production of Polyvinyl Alcohol/Carboxymethyl Cellulose Wound Healing Dressing Containing Sericin.Gels (Basel, Switzerland) · 2024Article
- Propionyl-l-carnitine mitigates ischemia-reperfusion injury in rat epigastric island flaps.Heliyon · 2024Article
- Natural agents as wound-healing promoters.Inflammopharmacology · 2024Review
- An Overview of Recent Developments in the Management of Burn Injuries.International journal of molecular sciences · 2023Review
- Characterization and Evaluation of Silk Sericin-Based Hydrogel: A Promising Biomaterial for Efficient Healing of Acute Wounds.ACS omega · 2023Article
- In vivo and in vitro studies of a propolis-enriched silk fibroin-gelatin composite nanofiber wound dressing.Heliyon · 2023Article
- Evaluation of the effects of three natural products and a hemostatic agent on wound healing: an experimental study.Turkish journal of medical sciences · 2023Article
- Engineered biomimetic micro/nano-materials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing.Biomolecules · 2022Review
- Effect of pheniramine maleate on rat skeletal muscle ischemia-reperfusion injury.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Response surface optimization of enzymatic hydrolysis and ROS scavenging activity of silk sericin hydrolysates.Pharmaceutical biology · 2022Article
- Recycled Sericin Hydrolysates Modified by AlcalaseInternational journal of molecular sciences · 2022Article
- Toxicological evaluation of water-extract sericin from silkworm (Frontiers in pharmacology · 2022Article
- Hybrid membrane of flat silk cocoon and carboxymethyl chitosan formed through hot pressing promotes wound healing and repair in a rat model.Frontiers in bioengineering and biotechnology · 2022Article
- Low Molecular Weight Sericin Enhances theFrontiers in bioengineering and biotechnology · 2022Article
- Urea-extracted sericin is potentially better than kojic acid in the inhibition of melanogenesis through increased reactive oxygen species generation.Journal of traditional and complementary medicine · 2021Article
- Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications.Journal of nanobiotechnology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats. MATERIAL/
methodsTwenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact control group. For other groups, a dorsal skin flap (9×3 cm) was drawn and pulled up with sharp dissection. The Sham operated group received no treatment. The Placebo group received placebo gel without sericin applied to the incision area once a day from day 0 to day 9. The Sericin Group 3 received 1% sericin gel applied to the incision area once a day from day 0 to day 9. Hematoxylin and eosin stain was applied for histological analysis and Mallory-Azan staining was applied for histoimmunochemical analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area.
resultsEpidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were increased in the sericin group.
conclusionsWe found that sericin had significant positive effects on wound healing and antioxidant activity. Sericin-based formulations can improve healing of incision wounds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.