Evidence map›Paper›PMID 27032496›Full record

ArticleVeterinary immunology and immunopathology2016

CpG DNA facilitate the inactivated transmissible gastroenteritis virus in enhancing the local and systemic immune response of pigs via oral administration.

Jian Lin, Chongzhi Tu, Chunxiao Mou, Xiaojuan Chen, Qian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary immunology and immunopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Noninvasive vaccination against infectious diseases.Human vaccines & immunotherapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jian LinCollege of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China.
Chongzhi TuCollege of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China.
Chunxiao MouCollege of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China.
Xiaojuan ChenCollege of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China.
Qian YangCollege of Veterinary Medicine, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China. Electronic address: zxbyq@njau.edu.cn.
Nanjing Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transmissible gastroenteritis virus (TGEV) replicates in the small intestine and induces enteritis and watery diarrhea. Establishment of local immunity in the intestine would thus prevent TGEV transmission. CpG DNA has been reported as a promising mucosal adjuvant in some animals. The effects of oral immunization of CpG DNA together with inactivated TGEV (ITGEV) were investigated in this study. Pigs (6 weeks old) were orally immunized with ITGEV plus CpG DNA. The TGEV-specific IgA level in the intestinal tract and the TGEV-specific IgG level in serum significantly increased following immunization with ITGEV plus CpG DNA (P ≤ 0.05). Moreover, populations of IgA-secreting cells, CD3+ T lymphocytes and intraepithelial lymphocytes (IELs), in the intestine increased significantly after immunization with ITGEV plus CpG DNA (P ≤ 0.05). Furthermore, the expression of IL-6, IL-12 and interferon-γ (IFN-γ) in ligated intestine segments increased significantly after injection with ITGEV plus CpG DNA (P ≤ 0.05). Taken together, these data suggest that oral immunization of ITGEV plus CpG DNA elicits a local immune response. Further studies are required to determine whether this immunity provides protection against TGEV in pigs.

Indexed as

Adjuvants, ImmunologicSwineAdministration, OphthalmicAnimalsAntibodies, ViralCytosine NucleotidesGastroenteritis, Transmissible, of SwineGC Rich SequenceGuanine NucleotidesImmunoglobulin AInterferon-gammaInterleukin-12Interleukin-6IntestinesSwine DiseasesT-LymphocytesAdjuvants, ImmunologicAntibodies, ViralCytosine NucleotidesGuanine NucleotidesImmunoglobulin AInterferon-gammaInterleukin-12Interleukin-6Vaccines, DNAVaccines, InactivatedViral VaccinesCpG DNAInactivated transmissible gastroenteritis virusLocal immunityOral immunizationPig

Identifiers

PMID27032496
PMCPMC7112793
OpenAlexW2283678302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.