Evidence map›Paper›PMID 27032388›Full record

ArticleMolecular neurobiology2017

Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine.

Else Eising, Reinald Shyti, Peter A C 't Hoen, Lisanne S Vijfhuizen, Sjoerd M H Huisman, Ludo A M Broos, Ahmed Mahfouz, Marcel J T Reinders, Michel D Ferrari, Else A Tolner and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Pooled it
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  18. Headache in people with epilepsy.Nature reviews. Neurology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Else EisingDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Reinald ShytiDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Peter A C 't HoenDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Lisanne S VijfhuizenDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Sjoerd M H HuismanDepartment of Intelligent Systems, Faculty of EEMCS, Delft University of Technology, Delft, Netherlands.
Ludo A M BroosDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Ahmed MahfouzDepartment of Intelligent Systems, Faculty of EEMCS, Delft University of Technology, Delft, Netherlands.
Marcel J T ReindersDepartment of Intelligent Systems, Faculty of EEMCS, Delft University of Technology, Delft, Netherlands.
Michel D FerrariDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Else A TolnerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Boukje de VriesDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Arn M J M van den MaagdenbergDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. A.M.J.M.van_den_Maagdenberg@lumc.nl.
Leiden University Medical Center · NLDelft University of Technology · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the α

Indexed as

AnimalsBinding SitesCerebral CortexCluster AnalysisCortical Spreading DepressionDisease Models, AnimalEpistasis, GeneticGene OntologyHigh-Throughput Nucleotide SequencingHumansInflammationMaleMice, Inbred C57BLMice, TransgenicMigraine DisordersProtein Interaction MapsTranscription FactorsDeep serial analysis of gene expressionFamilial hemiplegic migraine type 1Gene expression profilingInflammationInterferonMigraine

Identifiers

PMID27032388
PMCPMC5390001
OpenAlexW2329899724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.