ArticleJournal of the mechanical behavior of biomedical materials2016
Observation of direction-dependent mechanical properties in the human brain with multi-excitation MR elastography.
Article in Journal of the mechanical behavior of biomedical materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Effects and Correction of Patient Bulk Motion in Cranial DENSE MRI.Magnetic resonance in medicine · 2026Article
- Mechanical characterization of brain tissue: experimental techniques, human testing considerations, and perspectives.Acta biomaterialia · 2025Review
- Distinguishing shear and tensile myocardial wall stiffness using ex vivo anisotropic Magnetic Resonance Elastography.Acta biomaterialia · 2025Article
- Post-mortem changes of anisotropic mechanical properties in the porcine brain assessed by MR elastography.Brain multiphysics · 2024Article
- Shear wave speeds in a nearly incompressible fibrous material with two unequal fiber families.The Journal of the Acoustical Society of America · 2024Article
- Histology-informed multiscale modeling of human brain white matter.Scientific reports · 2023Article
- Mechanical stiffness and anisotropy measured by MRE during brain development in the minipig.NeuroImage · 2023Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- Imaging the subcellular viscoelastic properties of mouse oocytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transversely-isotropic brain in vivo MR elastography with anisotropic damping.Journal of the mechanical behavior of biomedical materials · 2023Article
- Reverberant magnetic resonance elastographic imaging using a single mechanical driver.Physics in medicine and biology · 2023Article
- OSCILLATE: A low-rank approach for accelerated magnetic resonance elastography.Magnetic resonance in medicine · 2022Article
- Mechanical Properties of the Extracellular Environment of Human Brain Cells Drive the Effectiveness of Drugs in Fighting Central Nervous System Cancers.Brain sciences · 2022Review
- Mapping heterogenous anisotropic tissue mechanical properties with transverse isotropic nonlinear inversion MR elastography.Medical image analysis · 2022Article
- Anisotropic mechanical properties in the healthy human brain estimated with multi-excitation transversely isotropic MR elastography.Brain multiphysics · 2022Article
- MR Imaging of Human Brain Mechanics In Vivo: New Measurements to Facilitate the Development of Computational Models of Brain Injury.Annals of biomedical engineering · 2021Review
- Axially- and torsionally-polarized radially converging shear wave MRE in an anisotropic phantom made via Embedded Direct Ink Writing.Journal of the mechanical behavior of biomedical materials · 2021Article
- Review
- MR elastography: Principles, guidelines, and terminology.Magnetic resonance in medicine · 2021Review
- Harnessing brain waves: a review of brain magnetic resonance elastography for clinicians and scientists entering the field.The British journal of radiology · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Magnetic resonance elastography (MRE) has shown promise in noninvasively capturing changes in mechanical properties of the human brain caused by neurodegenerative conditions. MRE involves vibrating the brain to generate shear waves, imaging those waves with MRI, and solving an inverse problem to determine mechanical properties. Despite the known anisotropic nature of brain tissue, the inverse problem in brain MRE is based on an isotropic mechanical model. In this study, distinct wave patterns are generated in the brain through the use of multiple excitation directions in order to characterize the potential impact of anisotropic tissue mechanics on isotropic inversion methods. Isotropic inversions of two unique displacement fields result in mechanical property maps that vary locally in areas of highly aligned white matter. Investigation of the corpus callosum, corona radiata, and superior longitudinal fasciculus, three highly ordered white matter tracts, revealed differences in estimated properties between excitations of up to 33%. Using diffusion tensor imaging to identify dominant fiber orientation of bundles, relationships between estimated isotropic properties and shear asymmetry are revealed. This study has implications for future isotropic and anisotropic MRE studies of white matter tracts in the human brain.
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