ArticlePloS one2016
Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Exploring the Impact of Platelet-Derived Growth Factor D in Pulmonary Hypertension Development.Pulmonary circulation · 2025Article
- Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions.Cellular and molecular life sciences : CMLS · 2024Article
- PDGF-D Is Dispensable for the Development and Progression of Murine Alport Syndrome.The American journal of pathology · 2024Article
- Review
- Abnormal Fetal Lung of Hoxa1Animals : an open access journal from MDPI · 2023Article
- Activin A Limits VEGF-Induced Permeability via VE-PTP.International journal of molecular sciences · 2023Article
- Molecular mechanisms of coronary artery disease risk at the PDGFD locus.Nature communications · 2023Article
- Molecular mechanisms of coronary artery disease risk at thebioRxiv : the preprint server for biology · 2023Article
- PDGFD switches on stem cell endothelial commitment.Angiogenesis · 2022Article
- E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR.The Journal of biological chemistry · 2022Article
- Review
- Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.Genome medicine · 2021Article
- PDGF receptor mutations in human diseases.Cellular and molecular life sciences : CMLS · 2021Review
- Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury.Oxidative medicine and cellular longevity · 2021Article
- Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction.Frontiers in cell and developmental biology · 2021Review
- Defining Endothelial Cell-Derived Factors That Promote Pericyte Recruitment and Capillary Network Assembly.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Verification and Analysis of Sheep Tail Type-AssociatedAnimals : an open access journal from MDPI · 2020Article
- Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival.American journal of physiology. Heart and circulatory physiology · 2019Article
- Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis.The Journal of clinical investigation · 2019Article
- Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure.Frontiers in cardiovascular medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platelet-derived growth factor D (PDGF-D) is the most recently discovered member of the PDGF family. PDGF-D signals through PDGF receptor β, but its biological role remains largely unknown. In contrast to other members of the PDGF family of growth factors, which have been extensively investigated using different knockout approaches in mice, PDGF-D has until now not been characterized by gene inactivation in mice. Here, we present the phenotype of a constitutive Pdgfd knockout mouse model (Pdgfd-/-), carrying a LacZ reporter used to visualize Pdgfd promoter activity. Inactivation of the Pdgfd gene resulted in a mild phenotype in C57BL/6 mice, and the offspring was viable, fertile and generally in good health. We show that Pdgfd reporter gene activity was consistently localized to vascular structures in both postnatal and adult tissues. The expression was predominantly arterial, often localizing to vascular bifurcations. Endothelial cells appeared to be the dominating source for Pdgfd, but reporter gene activity was occasionally also found in subpopulations of mural cells. Tissue-specific analyses of vascular structures revealed that NG2-expressing pericytes of the cardiac vasculature were disorganized in Pdgfd-/- mice. Furthermore, Pdgfd-/- mice also had a slightly elevated blood pressure. In summary, the vascular expression pattern together with morphological changes in NG2-expressing cells, and the increase in blood pressure, support a function for PDGF-D in regulating systemic arterial blood pressure, and suggests a role in maintaining vascular homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.