ArticleMedicine and science in sports and exercise2016
The Effect of Physical Activity on Passive Leg Movement-Induced Vasodilation with Age.
Article in Medicine and science in sports and exercise, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04013022 (The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses
Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Blood flow restriction in the presence or absence of muscle contractions does not preserve vasculature structure and function following 14-days of limb immobilization.European journal of applied physiology · 2021Trial
- The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Impaired nitric oxide-dependent endothelial function in young male individuals with obesity before the onset of symptoms and complications.Experimental physiology · 2026Article
- Commuting by bicycle (vs. by car) is associated with improved aerobic power, microvascular function and diminished COExperimental physiology · 2026Article
- Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS-CoV-2 infection.Experimental physiology · 2026Article
- Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Prolonged sitting reduces cerebral oxygenation in physically active young adults.Frontiers in cognition · 2024Article
- Lower limb hyperthermia augments functional hyperaemia during small muscle mass exercise similarly in trained elderly and young humans.Experimental physiology · 2023Article
- Reliability of the passive leg movement assessment of vascular function in men.Experimental physiology · 2022Article
- Impact of aging on the work of breathing during exercise in healthy men.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Article
- Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature.Nitric oxide : biology and chemistry · 2020Article
- Lifelong Endurance Exercise as a Countermeasure Against Age-RelatedSports medicine (Auckland, N.Z.) · 2020Review
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Physiological Impact and Clinical Relevance of Passive Exercise/Movement.Sports medicine (Auckland, N.Z.) · 2019Review
- The effect of the speed and range of motion of movement on the hyperemic response to passive leg movement.Physiological reports · 2019Article
- The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle.Frontiers in physiology · 2018Article
- Impact of Nitric Oxide Bioavailability on the Progressive Cerebral and Peripheral Circulatory Impairments During Aging and Alzheimer's Disease.Frontiers in physiology · 2018Article
- Single passive leg movement assessment of vascular function: contribution of nitric oxide.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- CORP: Ultrasound assessment of vascular function with the passive leg movement technique.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
introductionBecause of reduced nitric oxide (NO) bioavailability with age, passive leg movement (PLM)-induced vasodilation is attenuated in older sedentary subjects and, unlike the young subjects, cannot be augmented by posture-induced elevations in femoral perfusion pressure. However, whether vasodilator function assessed with PLM, and therefore NO bioavailability, is preserved in older individuals with greater physical activity and fitness is unknown.
methodsPLM was performed on four subject groups: young sedentary (Y, 23 ± 1 yr, n = 12), old sedentary (OS, 73 ± 2 yr, n = 12), old active (OA, 71 ± 2 yr, n = 10), and old endurance trained (OT, 72 ± 1 yr, n = 10) in the supine and upright-seated posture. Hemodynamics were measured using ultrasound Doppler and finger photoplethysmography.
resultsIn the supine posture, PLM-induced peak change in leg vascular conductance was significantly attenuated in the OS compared with the young subjects (OS = 4.9 ± 0.5, Y = 6.9 ± 0.7 mL·min·mm Hg) but was not different from the young in the OA and OT (OA = 5.9 ± 1.0, OT = 5.4 ± 0.4 mL·min·mm Hg). The upright-seated posture significantly augmented peak change in leg vascular conductance in all but the OS (OS = 4.9 ± 0.5, Y = 11.8 ± 1.3, OA = 7.3 ± 0.8, OT = 8.1 ± 0.8 mL·min·mm Hg), revealing a significant vasodilatory reserve capacity in the other groups (Y = 4.92 ± 1.18, OA = 1.37 ± 0.55, OT = 2.76 ± 0.95 mL·min·mm Hg).
conclusionsAs PLM predominantly reflects NO-mediated vasodilation, these findings support the idea that augmenting physical activity and fitness can protect NO bioavailability, attenuating the deleterious effects of advancing age on vascular function.
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Registered trials
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