ArticlePloS one2016
Identification and Pathogenic Potential of Clinical Bacillus and Paenibacillus Isolates.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 112 citations in OpenAlex.
- Assessment of pathogenic traits in selected bacteria isolated from snowy environments in France and Greenland.Extremophiles : life under extreme conditions · 2026Article
- Seasonal Influence on the Bioactive Profile of Essential Oil from AzoreanMolecules (Basel, Switzerland) · 2026Article
- Diagnostic challenges and therapeutic approach for aortic pseudoaneurysm infection withASM case reports · 2026Article
- Molecular identification and hydrolase activity profiling of bacteria isolated from septic surface environments using 16S rRNA sequencing.Molecular biology reports · 2026Article
- Diagnosis and treatment of infectious endocarditis caused by Paenibacillus lautus in a small-breed dog: a case report.BMC veterinary research · 2025Article
- Ecology and Pathogenicity for Honey Bee Brood of Recently Described Paenibacillus melissococcoides and Comparison With Paenibacillus dendritiformis, Paenibacillus thiaminolyticus.Environmental microbiology reports · 2025Article
- Systemic and localized infections in humans caused by Paenibacillus: a case report and literature review.BMC ophthalmology · 2025Review
- Isolation, identification, and sensitivity profile ofFrontiers in pediatrics · 2025Article
- Resolution of MALDI-TOF compared to whole genome sequencing for identification ofFrontiers in microbiology · 2025Article
- Bacillus mycoides bacteremia after dog bite trauma in a patient on chronic suppressive antibiotics.IDCases · 2025Article
- Disrupted gut microbiota promotes the progression of chronic kidney disease in 5/6 nephrectomy mice byFrontiers in cellular and infection microbiology · 2025Article
- Microbial richness and air chemistry in aerosols above the PBL confirm 2,000-km long-distance transport of potential human pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Characterization by MALDI-TOF MS and 16S rRNA Gene Sequencing of Aerobic Endospore-Forming Bacteria Isolated from Pharmaceutical Facility in Rio de Janeiro, Brazil.Microorganisms · 2024Article
- Heterotrophic bacteria in drinking water: evaluating antibiotic resistance and the presence of virulence genes.Microbiology spectrum · 2024Article
- MALDI-TOF as a powerful tool for identifying and differentiating closely related microorganisms: the strange case of three reference strains of Paenibacillus polymyxa.Scientific reports · 2024Article
- Uncommon Septic Arthritis of the Hip Joint in an Immunocompetent Adult Patient Due toPharmaceuticals (Basel, Switzerland) · 2023Article
- [Skin infection by Bacillus licheniformis].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2023Article
- Article
- Seasonal Changes in the Microbial Communities on Lettuce (Journal of microbiology and biotechnology · 2023Article
- Prevalence, Virulence Potential, and Growth in Cheese ofMicroorganisms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The soil-related Bacillus and Paenibacillus species have increasingly been implicated in various human diseases. Nevertheless, their identification still poses problems in the clinical microbiology laboratory and, with the exception of Bacillus anthracis and Bacillus cereus, little is known on their pathogenicity for humans. In this study, we evaluated the use of matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) in the identification of clinical isolates of these genera and conducted genotypic and phenotypic analyses to highlight specific virulence properties. Seventy-five clinical isolates were subjected to biochemical and MALDI-TOF MS identification. 16S rDNA sequencing and supplemental tests were used to solve any discrepancies or failures in the identification results. MALDI-TOF MS significantly outperformed classical biochemical testing for correct species identification and no misidentification was obtained. One third of the collected strains belonged to the B. cereus species, but also Bacillus pumilus and Bacillus subtilis were isolated at high rate. Antimicrobial susceptibility testing showed that all the B. cereus, B. licheniformis, B. simplex, B. mycoides, Paenibacillus glucanolyticus and Paenibacillus lautus isolates are resistant to penicillin. The evaluation of toxin/enzyme secretion, toxin-encoding genes, motility, and biofilm formation revealed that B. cereus displays the highest virulence potential. However, although generally considered nonpathogenic, most of the other species were shown to swim, swarm, produce biofilms, and secrete proteases that can have a role in bacterial virulence. In conclusion, MALDI-TOF MS appears useful for fast and accurate identification of Bacillus and Paenibacillus strains whose virulence properties make them of increasing clinical relevance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.