ArticlePloS one2016
Normal Lung Quantification in Usual Interstitial Pneumonia Pattern: The Impact of Threshold-based Volumetric CT Analysis for the Staging of Idiopathic Pulmonary Fibrosis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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31 citing papers in PubMed, 63 citations in OpenAlex.
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- Interstitial Lung Disease Outcome Prediction Using Quantitative Densitometry Indices on Baseline Chest Computed Tomography.Diagnostics (Basel, Switzerland) · 2025Article
- Effect of slice thickness on quantitative analysis of interstitial lung disease: a retrospective volumetric chest CT study.La Radiologia medica · 2025Article
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- Prognostic value of computed tomography assessment of normal lung volume in upper lobe in idiopathic pleuroparenchymal fibroelastosis.ERJ open research · 2025Article
- The Significance of Density Measurement and the Modified Bhalla and Reiff Scores in Predicting Exacerbations and Hospital Admissions in Cystic Fibrosis Patients.Medicina (Kaunas, Lithuania) · 2025Article
- How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?Annals of nuclear medicine · 2024Article
- Quantitative CT analysis of idiopathic pulmonary fibrosis and correlation with lung function study.BMC pulmonary medicine · 2024Article
- Estimation of threshold thickness of residual normal tissue in lung dysfunction detectable by dynamic chest radiography: A virtual imaging trial.Medical physics · 2024Article
- Productive cough associated with patient-reported outcomes and computed tomography analysis results in idiopathic pulmonary fibrosis: a single centre cross-sectional study.ERJ open research · 2024Article
- Quantitative Analysis for Lung Disease on Thin-Section CT.Diagnostics (Basel, Switzerland) · 2023Review
- Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Differences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis.Scientific reports · 2022Article
- How Artificial Intelligence in Imaging Can Better Serve Patients with Bronchial and Parenchymal Lung Diseases?Journal of personalized medicine · 2022Review
- Association of quantitative computed tomography ındices with lung function and extent of pulmonary fibrosis in patients with systemic sclerosis.Clinical rheumatology · 2022Article
- Radiomics-based machine learning differentiates "ground-glass" opacities due to COVID-19 from acute non-COVID-19 lung disease.Scientific reports · 2021Article
- Evolution of CT Findings and Lung Residue in Patients with COVID-19 Pneumonia: Quantitative Analysis of the Disease with a Computer Automatic Tool.Journal of personalized medicine · 2021Article
- The impact of lung parenchyma attenuation on nodule volumetry in lung cancer screening.Insights into imaging · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough several computer-aided computed tomography (CT) analysis methods have been reported to objectively assess the disease severity and progression of idiopathic pulmonary fibrosis (IPF), it is unclear which method is most practical. A universal severity classification system has not yet been adopted for IPF.
objectiveThe purpose of this study was to test the correlation between quantitative-CT indices and lung physiology variables and to determine the ability of such indices to predict disease severity in IPF.
methodsA total of 27 IPF patients showing radiological UIP pattern on high-resolution (HR) CT were retrospectively enrolled. Staging of IPF was performed according to two classification systems: the Japanese and GAP (gender, age, and physiology) staging systems. CT images were assessed using a commercially available CT imaging analysis workstation, and the whole-lung mean CT value (MCT), the normally attenuated lung volume as defined from -950 HU to -701 Hounsfield unit (NL), the volume of the whole lung (WL), and the percentage of NL to WL (NL%), were calculated.
resultsCT indices (MCT, WL, and NL) closely correlated with lung physiology variables. Among them, NL strongly correlated with forced vital capacity (FVC) (r = 0.92, P <0.0001). NL% showed a large area under the receiver operating characteristic curve for detecting patients in the moderate or advanced stages of IPF. Multivariable logistic regression analyses showed that NL% is significantly more useful than the percentages of predicted FVC and predicted diffusing capacity of the lungs for carbon monoxide (Japanese stage II/III/IV [odds ratio, 0.73; 95% confidence intervals (CI), 0.48 to 0.92; P < 0.01]; III/IV [odds ratio. 0.80; 95% CI 0.59 to 0.96; P < 0.01]; GAP stage II/III [odds ratio, 0.79; 95% CI, 0.56 to 0.97; P < 0.05]).
conclusionThe measurement of NL% by threshold-based volumetric CT analysis may help improve IPF staging.
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