SynthesisMedicina oral, patologia oral y cirugia bucal2016
Treatment of xerostomia and hyposalivation in the elderly: A systematic review.
Synthesis in Medicina oral, patologia oral y cirugia bucal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study to Evaluate the Efectiveness and Tolerability of a New Gel for Xerostomia
Effectiveness of C02 Microfractionated Laser in Conjunction With Topical Regenerative Therapy in the Management of Vulvo-vaginal Atrophy in Patients With a History of Breast Cancer. Randomized Experimental and Comparative Study.
Efficacy of Submucosal Hyaluronic Acid Infiltration in Improving the Sensation of Dry Mouth in Patients With Xerostomia: A Double-Blind Randomized Clinical Trial.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Dental approach for Apert syndrome in children: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2017Pooled it
- Comparison of transcutaneous electrical nerve stimulation and interferential therapy for salivary stimulation in postmenopausal women: a pilot study.Scientific reports · 2026Trial
- Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial.Brazilian oral research · 2025Trial
- Sodium-hyaluronate mouthwash on radiotherapy-induced xerostomia: a randomised clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Trial
- Effects of the salivary gland massage program in older type 2 diabetes patients on the salivary flow rate, xerostomia, swallowing and oral hygiene: A randomized controlled trial.Geriatrics & gerontology international · 2023Trial
- Effect of a newly developed pastille on the salivary flow rate in subjects with dry mouth symptoms: a randomized, controlled, monocentric clinical study.BMC oral health · 2021Trial
- Polypharmacy, salivary function, and oral health outcomes in institutionalized older adults: A scoping review.Journal of clinical and experimental dentistry · 2026Review
- Histopathology of the tongue in a hamster model of COVID-19.BMC oral health · 2025Article
- Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review.Journal of clinical and experimental dentistry · 2024Review
- Volume changes in the contralateral submandibular gland following unilateral gland excision in oral cancer patients.Maxillofacial plastic and reconstructive surgery · 2024Article
- Histopathology of the Tongue in a Hamster Model of COVID-19.Research square · 2024Article
- Benchmarking of a microgel-reinforced hydrogel-based aqueous lubricant against commercial saliva substitutes.Scientific reports · 2023Article
- A scoping review on hyposalivation associated with systemic conditions: the role of physical stimulation in the treatment approaches.BMC oral health · 2023Article
- Oral Mucosa in Cancer Patients-Putting the Pieces Together: A Narrative Review and New Perspectives.Cancers · 2023Review
- The Impact of Commercially Available Dry Mouth Products on the Corrosion Resistance of Common Dental Alloys.Materials (Basel, Switzerland) · 2023Article
- Dysphagia in Parkinson Disease: Part II-Current Treatment Options and Insights from Animal Research.Current physical medicine and rehabilitation reports · 2023Article
- Oral Conditions as Risk Factors for Low Oral Health-Related Quality of Life Among the Elderly Population in Yogyakarta, Indonesia.European journal of dentistry · 2023Article
- Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats.Aging · 2023Article
- Cell-Free Therapies: The Use of Cell Extracts to Mitigate Irradiation-Injured Salivary Glands.Biology · 2023Review
- Xerogenic medications may contribute to decreased unstimulated salivary flow in patients with oral burning and/or gastro-esophageal reflux disease.Frontiers in dental medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTherapeutic strategies for xerostomia, regardless of etiology, have so far not had definitive or clearly effective results.
objectivesTo systematically revise the latest scientific evidence available regarding the treatment of dry mouth, regardless of the cause of the problem. MATERIAL AND
methodsThe literature search was conducted in March 2015, using the Medline and Embase databases. The "Clinical Trial", from 2006 to March 2015, was carried out in English and only on human cases. The draft of the systematic review and assessment of the methodological quality of the trials was carried out following the criteria of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and the "Oxford Quality Scale".
resultsFinally, a total of 26 trials were identified that met the previously defined selection and quality criteria; 14 related to drug treatments for dry mouth, 10 with non-pharmacological treatment and 2 with alternative treatments.
conclusionsPilocarpine continues to be the best performing sialogogue drug for subjects with xerostomia due to radiation on head and neck cancer or diseases such as Sjogren's Syndrome. For patients with dry mouth caused solely by medication, there are some positive indications from the use of malic acid, along with other elements that counteract the harmful effect on dental enamel. In general, lubrication of oral mucous membrane reduces the symptoms, although the effects are short-lived.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.