Evidence map›Paper›PMID 27030789›Full record

ArticlePsychological inquiry

The Power of Theory, Research Design, and Transdisciplinary Integration in Moving Psychopathology Forward.

Uma Vaidyanathan, Scott I Vrieze, William G Iacono

Abstract read
In one paragraph

Article in Psychological inquiry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Advancing clinical psychology with improved doctoral training in science.Training and education in professional psychology · 2026
    Article
  2. Theories of psychopathology: Introduction to a special section.Journal of psychopathology and clinical science · 2023
    Article
  3. Article
  4. Article
  5. The p factor is the sum of its parts, for now.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Testing the effects of adolescent alcohol use on adult conflict-related theta dynamics.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2017
    Article
  12. Endophenotype best practices.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Review
  13. Article
  14. Moving Psychopathology Forward.Psychological inquiry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Uma VaidyanathanDepartment of Psychology, University of Minnesota, N218 Elliot Hall, 75 East River Road, Minneapolis, MN 55455.
Scott I VriezeInstitute for Behavioral Genetics, University of Colorado - Boulder, 1480 30 Street, Boulder, CO 80303.
William G IaconoDepartment of Psychology, University of Minnesota, N218 Elliot Hall, 75 East River Road, Minneapolis, MN 55455.

Funding

Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
TWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0M
Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
A Longitudinal Study of Adopted Youth and Their FamiliesR01MH066140 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 2003 to 2013
$5.8M
TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5M
Adolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4M
TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0M
Adult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2M
Genetic Association Meta-Analyses of Smoking and Drinking for the Sequencing AgeR01DA037904 · NIDA · UNIVERSITY OF MINNESOTA · PI VRIEZE, SCOTT IAN · 2015 to 2019
$2.4M
Social Media, Online Measures, and Substance Use Development in Adolescent TwinsR01AA023974 · NIAAA · UNIVERSITY OF COLORADO · PI VRIEZE, SCOTT IAN · 2014 to 2016
$1.6M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentR01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2011 to 2011
$1.6M
Delineating Gene, Environment, & Development Interplay in Substance Use DisordersR01DA034606 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HICKS, BRIAN M · 2013 to 2015
$706k
NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA023974NIAAA NIH HHS R37 AA009367NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA034606NIDA NIH HHS R01 DA036216NIDA NIH HHS R01 DA037904NIDA NIH HHS R37 DA005147NIDA NIH HHS U01 DA024417NIMH NIH HHS R01 MH066140
6 · The paper itself

Abstract

While the past few decades have seen much work in psychopathology research that has yielded provocative insights, relatively little progress has been made in understanding the etiology of mental disorders. We contend that this is due to an overreliance on statistics and technology with insufficient attention to adequacy of experimental design, a lack of integration of data across various domains of research, and testing of theoretical models using relatively weak study designs. We provide a conceptual discussion of these issues and follow with a concrete demonstration of our proposed solution. Using two different disorders - depression and substance use - as examples, we illustrate how we can evaluate competing theories regarding their etiology by integrating information from various domains including latent variable models, neurobiology, and quasi-experimental data such as twin and adoption studies, rather than relying on any single methodology alone. More broadly, we discuss the extent to which such integrative thinking allows for inferences about the etiology of mental disorders, rather than focusing on descriptive correlates alone. Greater scientific insight will require stringent tests of competing theories and a deeper conceptual understanding of the advantages and pitfalls of methodologies and criteria we use in our studies.

Indexed as

Etiology of mental disordersNeurobiologyPitfalls and advantages of technology and statistical modelingQuasi-experimental designsTheory vs data-driven approaches

Identifiers

PMID27030789
PMCPMC4809358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.