ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Comparison of compensatory reserve during lower-body negative pressure and hemorrhage in nonhuman primates.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04457817 (CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients With COVID-19), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CRI and Continuous Assessment of Hemodynamic Compensation to Guide Fluid and Pressor Management in Severely Ill Patients With COVID-19
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Cardiovascular reserve as an integrative physiological construct: Current evidence, emerging technologies and future directions.Clinical physiology and functional imaging · 2026Review
- Characteristics of sustained attention impairment in individuals under simulated positive acceleration stress: separation effect of early and late stage cognitive processing.Frontiers in behavioral neuroscience · 2026Article
- Sympathetic vasomotion as an early marker of hemorrhage.Frontiers in physiology · 2025Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Superiority of compensatory reserve measurement compared with the Shock index for early and accurate detection of reduced central blood volume status.The journal of trauma and acute care surgery · 2023Article
- Article
- Impact of Increasing Lower Body Negative Pressure and Its Abrupt Release on Left Ventricular Hemodynamics in Anesthetized Pigs.Journal of clinical medicine · 2022Article
- Measurement of intravascular volume status in infants undergoing cranial vault reconstruction for craniosynostosis.Surgery in practice and science · 2022Article
- AI-Enabled Advanced Development for Assessing Low Circulating Blood Volume for Emergency Medical Care: Comparison of Compensatory Reserve Machine-Learning Algorithms.Sensors (Basel, Switzerland) · 2022Article
- Baseline Values of the Compensatory Reserve Index in a Healthy Pediatric Population.Pediatric cardiology · 2022Article
- Wearable Sensors Incorporating Compensatory Reserve Measurement for Advancing Physiological Monitoring in Critically Injured Trauma Patients.Sensors (Basel, Switzerland) · 2020Review
- Enabling the assessment of trauma-induced hemorrhage via smart wearable systems.Science advances · 2020Article
- Article
- Bridging the gap between military prolonged field care monitoring and exploration spaceflight: the compensatory reserve.NPJ microgravity · 2019Review
- Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women.The journal of trauma and acute care surgery · 2018Article
- Effect of acute hypoxemia on cerebral blood flow velocity control during lower body negative pressure.Physiological reports · 2018Article
- The physiology of blood loss and shock: New insights from a human laboratory model of hemorrhage.Experimental biology and medicine (Maywood, N.J.) · 2017Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Compensatory reserve was measured in baboons (n = 13) during hemorrhage (Hem) and lower-body negative pressure (LBNP) using a machine-learning algorithm developed to estimate compensatory reserve by detecting reductions in central blood volume during LBNP. The algorithm calculates compensatory reserve index (CRI) from normovolemia (CRI = 1) to cardiovascular decompensation (CRI = 0). The hypothesis was that Hem and LBNP will elicit similar CRI values and that CRI would have higher specificity than stroke volume (SV) in predicting decompensation. Blood was removed in four steps: 6.25%, 12.5%, 18.75%, and 25% of total blood volume. Four weeks after Hem, the same animals were subjected to four levels of LBNP that was matched on the basis of their central venous pressure. Data (mean ± 95% confidence interval) indicate that CRI decreased (P < 0.001) from baseline during Hem (0.69 ± 0.10, 0.57 ± 0.09, 0.36 ± 0.10, 0.16 ± 0.08, and 0.08 ± 0.03) and LBNP (0.76 ± 0.05, 0.66 ± 0.08, 0.36 ± 0.13, 0.23 ± 0.11, and 0.14 ± 0.09). CRI was not different between Hem and LBNP (P = 0.20). Linear regression analysis between Hem CRI and LBNP CRI revealed a slope of 1.03 and a correlation coefficient of 0.96. CRI exhibited greater specificity than SV in both Hem (92.3 vs. 82.1) and LBNP (94.8 vs. 83.1) and greater ROC AUC in Hem (0.94 vs. 0.84) and LBNP (0.94 vs. 0.92). These data support the hypothesis that Hem and LBNP elicited the same CRI response, suggesting that measurement of compensatory reserve is superior to SV as a predictor of cardiovascular decompensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.