Evidence map›Paper›PMID 27030640›Full record

ArticleJournal of microbiological methods2016

Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation.

Mark Reglinski, Nicola N Lynskey, Shiranee Sriskandan

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiological methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark ReglinskiFaculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom. Electronic address: m.reglinski10@imperial.ac.uk.
Nicola N LynskeyFaculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom.
Shiranee SriskandanFaculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, United Kingdom. Electronic address: s.sriskandan@imperial.ac.uk.

Funding

Medical Research Council G0800777Medical Research Council MC_PC_12015
6 · The paper itself

Abstract

The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity using stored samples.

Indexed as

Antibodies, BacterialBacterial ProteinsHumansImmunoassayStreptococcal InfectionsStreptococcus pyogenesAntibodies, BacterialBacterial ProteinsMac-1-like protein, StreptococcusGroup A streptococcusLancefield assayStreptococcus pyogenesSurrogate of immunity

Identifiers

PMID27030640
PMCPMC4838658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.