Evidence map›Paper›PMID 27030587›Full record

ArticleClinical and vaccine immunology : CVI2016

Opsonophagocytic Assay To Evaluate Immunogenicity of Nontyphoidal Salmonella Vaccines.

Girish Ramachandran, Mary Adetinuke Boyd, Jennifer MacSwords, Ellen E Higginson, Raphael Simon, James E Galen, Marcela F Pasetti, Myron M Levine, Sharon M Tennant

Open access · diamondAbstract readEvaluation Study
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Girish RamachandranCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Mary Adetinuke BoydCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jennifer MacSwordsCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ellen E HigginsonCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Raphael SimonCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
James E GalenCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Marcela F PasettiCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Myron M LevineCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Sharon M TennantCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA stennant@medicine.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GEDDES, CHRISTOPHER DARREN · 2003 to 2013
$91.5M
NIAID NIH HHS U54 AI057168
6 · The paper itself

Abstract

Nontyphoidal Salmonella (NTS) invasive infections are an important cause of morbidity and mortality in sub-Saharan Africa. Several vaccines are in development to prevent these infections. We describe an NTS opsonophagocytic killing assay that uses HL-60 cells and baby rabbit complement to quantify functional antibodies elicited by candidate NTS vaccines.

Indexed as

Immunogenicity, VaccinePhagocytosisAnimalsAntibodies, BacterialChild, PreschoolComplement System ProteinsHL-60 CellsHumansImmunoglobulin GMiceRabbitsSalmonellaSalmonella InfectionsSalmonella Infections, AnimalSalmonella typhimuriumSalmonella VaccinesAntibodies, BacterialComplement System ProteinsImmunoglobulin GSalmonella Vaccines

Identifiers

PMID27030587
PMCPMC4895007
OpenAlexW2328358628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.