Evidence map›Paper›PMID 27030441›Full record

ArticleThe Journal of organic chemistry2016

One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies.

Alex L Bagdasarian, Huy H Nguyen, Teresa A Palazzo, James C Fettinger, Makhluf J Haddadin, Mark J Kurth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Novel 2-(5-Imino-5ACS omega · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alex L BagdasarianDepartment of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
Huy H NguyenDepartment of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
Teresa A PalazzoDepartment of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
James C FettingerDepartment of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.
Makhluf J HaddadinDepartment of Chemistry, American University of Beirut , Beirut 1107 2020, Lebanon.
Mark J KurthDepartment of Chemistry, University of California , One Shields Avenue, Davis, California 95616, United States.

Funding

SynthesisP30DK072517 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2005 to 2022
$18.1M
Complex Heterocycles and Hybrid Strategies for Pilot Scale LibrariesP41GM089153 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KURTH, MARK J. · 2010 to 2012
$1.1M
NIDDK NIH HHS P30 DK072517NIGMS NIH HHS P41 GM089153
6 · The paper itself

Abstract

Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.

Indexed as

BenzimidazolesCatalysisCyclizationIsoquinolinesMolecular StructureQuinoxalinesBenzimidazolesbenzo(4,5)imidazo(2,1-a)isoquinolineIsoquinolinesisoquinolino(3,4-b)quinoxalineQuinoxalines

Identifiers

PMID27030441
PMCPMC6688609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.