Evidence map›Paper›PMID 27030392›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2016

The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells.

Hongliang Li, Han Sol Kim, Hye Won Kim, Sung Eun Shin, Won-Kyo Jung, Kwon-Soo Ha, Eun-Taek Han, Seok-Ho Hong, Amy L Firth, Young Min Bae and 2 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Inhibition of voltage-dependent KThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Hongliang LiInstitute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 200-701, South Korea.
Han Sol KimInstitute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 200-701, South Korea.
Hye Won KimInstitute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 200-701, South Korea.
Sung Eun ShinInstitute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 200-701, South Korea.
Won-Kyo JungDepartment of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 608-737, South Korea.
Kwon-Soo HaDepartment of Molecular and Cellular Biochemistry, Kangwon National University School of Medicine, Chuncheon, 200-701, South Korea.
Eun-Taek HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 200-701, South Korea.
Seok-Ho HongInstitute of Medical Sciences, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, 200-701, South Korea.
Amy L FirthDepartment of Pulmonary, Critical Care and Sleep Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA.
Young Min BaeDepartment of Physiology, Konkuk University School of Medicine, Chungju, 380-701, South Korea.
Il-Whan ChoiDepartment of Microbiology, Inje University College of Medicine, Busan, 614-735, South Korea. cihima@inje.ac.kr.
Won Sun ParkInstitute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon, 200-701, South Korea. parkws@kangwon.ac.kr.
Kangwon National University · KRInje University · KRKonkuk University · KRPukyong National University · KRUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the inhibitory effect of amiodarone, a class III anti-arrhythmic agent, on voltage-dependent K(+) (Kv) currents in freshly isolated rabbit coronary arterial smooth muscle cells, using a whole-cell patch clamp technique. Amiodarone inhibited Kv currents in a concentration-dependent manner, with a half-maximal inhibitory concentration (IC50) value of 3.9 ± 1.44 μM and a Hill coefficient of 0.45 ± 0.14. Amiodarone did not have a significant effect on the steady-state activation of Kv channels, but shifted the inactivation current toward a more negative potential. Application of consecutive pulses progressively augmented the amiodarone-induced Kv channel inhibition. Another class III anti-arrhythmic agent, dofetilide, did not inhibit the Kv current or change the inhibitory effect of amiodarone on Kv channels. Therefore, these results strongly suggest that amiodarone inhibits Kv currents in a concentration- and state-dependent manner.

Indexed as

AmiodaroneAnimalsAnti-Arrhythmia AgentsCoronary VesselsDose-Response Relationship, DrugIon Channel GatingKv1.5 Potassium ChannelMaleMembrane PotentialsMuscle, Smooth, VascularMyocytes, Smooth MusclePatch-Clamp TechniquesPotassium Channel BlockersPotassium Channels, Voltage-GatedRabbitsAmiodaroneAnti-Arrhythmia AgentsKv1.5 Potassium ChannelPotassium Channel BlockersPotassium Channels, Voltage-GatedAmiodaroneCoronary arteryVoltage-dependent K+ channel

Identifiers

PMID27030392
OpenAlexW2332685362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.