Evidence map›Paper›PMID 27030312›Full record

ArticleDiabetologia2016

Risk of epilepsy in type 1 diabetes mellitus: a population-based cohort study.

I-Ching Chou, Chung-Hsing Wang, Wei-De Lin, Fuu-Jen Tsai, Che-Chen Lin, Chia-Hung Kao

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Type 1 diabetes and the risk of epilepsy: A meta-analysis.Journal of diabetes investigation · 2024
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  14. The JAK-STAT Signaling Pathway in Epilepsy.Current neuropharmacology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

I-Ching ChouDepartment of Pediatric Neurology, China Medical University Children's Hospital, Taichung, Taiwan.
Chung-Hsing WangDepartment of Pediatric Neurology, China Medical University Children's Hospital, Taichung, Taiwan.
Wei-De LinDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Fuu-Jen TsaiDepartment of Pediatric Neurology, China Medical University Children's Hospital, Taichung, Taiwan.
Che-Chen LinSchool of Medicine, China Medical University, Taichung, Taiwan.
Chia-Hung KaoGraduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung, 40447, Taiwan. d10040@mail.cmuh.org.tw.
China Medical University · TWAsia University · TWChina Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisType 1 diabetes mellitus is a major public health problem of increasing global concern, with potential neurological complications. A possible association exists between type 1 diabetes and subsequent epilepsy. This study evaluated the relationship between type 1 diabetes and epilepsy in Taiwan.

methodsClaims data from the Taiwan National Health Insurance Research Database were used to conduct retrospective cohort analyses. The study cohort contained 2568 patients with type 1 diabetes, each of whom was frequency-matched by sex, urbanisation of residence area and index year with ten patients without type 1 diabetes. Cox proportional hazard regression analysis was conducted to estimate the effects of type 1 diabetes on epilepsy risk.

resultsIn patients with type 1 diabetes, the risk of developing epilepsy was significantly higher than that in patients without type 1 diabetes (p < 0.0001 for logrank test). After adjustment for potential confounders, the type 1 diabetes cohort was 2.84 times as likely to develop epilepsy than the control cohort was (HR 2.84 [95% CI 2.11, 3.83]). CONCLUSIONS/

interpretationPatients with type 1 diabetes are at an increased risk of developing epilepsy. Metabolic abnormalities of type 1 diabetes, such as hyperglycaemia and hypoglycaemia, may have a damaging effect on the central nervous system and be associated with significant long-term neurological sequelae. The causative factors between type 1 diabetes and the increased risk of epilepsy require further investigation.

Indexed as

AdolescentChildCohort StudiesDiabetes Mellitus, Type 1EpilepsyFemaleHumansHyperglycemiaHypoglycemiaMaleProportional Hazards ModelsRetrospective StudiesRisk FactorsEpilepsyNational Health Insurance Research DatabaseType 1 diabetes

Identifiers

PMID27030312
OpenAlexW2328874926

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.