ArticleScientific reports2016
The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 138 citations in OpenAlex.
- Amino acid metabolism by pig intestinal bacteria and consequences for intestinal health and environment: current knowledge and future directions.Journal of animal science and biotechnology · 2026Review
- The Effect of Hydrogen Sulfide and Reactive Sulfur Species on Bacterial Virulence and Antibiotic Sensitivity.International journal of molecular sciences · 2026Review
- Effect of Ammonia onAntioxidants (Basel, Switzerland) · 2026Article
- Whole-genome characterization and analysis of Pantoea agglomerans R6: a genomic insight into its pathogenicity and resistance as a potential opportunistic plant pathogen.BMC genomics · 2026Article
- Oxygen reductase origin followed the great oxidation event and terminated the Lomagundi excursion.Biochimica et biophysica acta. Bioenergetics · 2026Article
- Self-bioRxiv : the preprint server for biology · 2026Article
- Role of hydrogen sulfide in bacterial antibiotic tolerance: from mechanisms to therapeutic targeting.Frontiers in cellular and infection microbiology · 2026Review
- Recycling of Undigested Proteins Provided by the Host to the Large Intestine Microbiota: Implication for Intestinal Bacterial Anabolism, Growth, and Physiology.Microorganisms · 2025Review
- Article
- Hydrogen Oxidation Benefits Alphaproteobacterial Methanotrophs Under Severe Methane Limitation.Environmental microbiology · 2025Article
- Carbon Monoxide and Prokaryotic Energy Metabolism.International journal of molecular sciences · 2025Review
- HNature communications · 2024Article
- The radical impact of oxygen on prokaryotic evolution-enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third.FEBS letters · 2024Article
- Cyanide Insensitive Oxidase Confers Hydrogen Sulfide and Nitric Oxide Tolerance toAntioxidants (Basel, Switzerland) · 2024Article
- Harnessing Fermentation May Enhance the Performance of Biological Sulfate-Reducing Bioreactors.Environmental science & technology · 2024Article
- Membrane-Bound Redox Enzyme CytochromeInternational journal of molecular sciences · 2024Article
- Identification of genes associated with persistence inFrontiers in microbiology · 2024Article
- Genome features of a novel hydrocarbonoclastic Chryseobacterium oranimense strain and its comparison to bacterial oil-degraders and to other C. oranimense strains.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Influence of Growth Medium Composition on Physiological Responses ofBiotech (Basel (Switzerland)) · 2023Article
- Simultaneous sulfide and methane oxidation by an extremophile.Nature communications · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulfide (H2S) impairs mitochondrial respiration by potently inhibiting the heme-copper cytochrome c oxidase. Since many prokaryotes, including Escherichia (E.) coli, generate H2S and encounter high H2S levels particularly in the human gut, herein we tested whether bacteria can sustain sulfide-resistant O2-dependent respiration. E. coli has three respiratory oxidases, the cyanide-sensitive heme-copper bo3 enzyme and two bd oxidases much less sensitive to cyanide. Working on the isolated enzymes, we found that, whereas the bo3 oxidase is inhibited by sulfide with half-maximal inhibitory concentration IC50 = 1.1 ± 0.1 μM, under identical experimental conditions both bd oxidases are insensitive to sulfide up to 58 μM. In E. coli respiratory mutants, both O2-consumption and aerobic growth proved to be severely impaired by sulfide when respiration was sustained by the bo3 oxidase alone, but unaffected by ≤200 μM sulfide when either bd enzyme acted as the only terminal oxidase. Accordingly, wild-type E. coli showed sulfide-insensitive respiration and growth under conditions favouring the expression of bd oxidases. In all tested conditions, cyanide mimicked the functional effect of sulfide on bacterial respiration. We conclude that bd oxidases promote sulfide-resistant O2-consumption and growth in E. coli and possibly other bacteria. The impact of this discovery is discussed.
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