ArticleScientific reports2016
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- NAPQI adducts in patients with selective hypersensitivity to acetaminophen.Frontiers in pharmacology · 2026Article
- Mixed Shock due to Sepsis and Anaphylactic Reaction With Kounis Syndrome Secondary to Dipyrone (Metamizole): Case Report.Case reports in critical care · 2026Article
- To use or not to use: Safety of selected painkillers in patients with chronic liver diseases.Clinical and experimental hepatology · 2025Review
- Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis.Molecules (Basel, Switzerland) · 2024Article
- Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis.Immunity, inflammation and disease · 2024Article
- Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose.Drugs in R&D · 2023Article
- Article
- NSAID Hypersensitivity in the Pediatric Population: Classification and Diagnostic Strategies.Journal of asthma and allergy · 2022Review
- The role of heme oxygenase-1 in hematopoietic system and its microenvironment.Cellular and molecular life sciences : CMLS · 2021Review
- Lack of Major Involvement of CommonFrontiers in pharmacology · 2021Article
- Clinical Manifestations and Causes of Anaphylaxis. Analysis of 382 Cases from the Anaphylaxis Registry in West Pomerania Province in Poland.International journal of environmental research and public health · 2020Article
- Basophil Activation Experiments in Immediate Drug Hypersensitivity: More Than a Diagnostic Aid.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Acute intermittent porphyria: analgesia can be dangerous.BMJ case reports · 2019Article
- BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?Current allergy and asthma reports · 2019Review
- Acute Liver Failure in a Patient Treated With Metamizole.Frontiers in pharmacology · 2019Article
- NSAID-induced reactions: classification, prevalence, impact, and management strategies.Journal of asthma and allergy · 2019Review
- Response to Ebo et al., Letter to the Editor Regarding Update on Quinolone Allergy.Current allergy and asthma reports · 2017Article
- The using of a piglets as a model for evaluating the dipyrone hematological effects.BMC veterinary research · 2016Article
- FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.Frontiers in pharmacology · 2016Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of hypersensitivity reactions, with pyrazolones the most frequent drugs inducing selective reactions. Immediate selective hypersensitivity to pyrazolones is thought to be mediated by specific-IgE. Sensitivity of in vitro diagnostic tests is low and this may be due to the incomplete characterization of the structures involved. Here we investigated whether main metabolites of metamizole (dipyrone) in human could be involved in the immune response using the basophil activation test (BAT). We studied subjects with confirmed selective immediate hypersensitivity to metamizole and performed BAT with metamizole and its metabolites: 4-methylamino-antipyrine (MAA), 4-aminoantipyrine (AA), 4-acetylamino-antipyrine (AAA) and 4-formylamino-antipyrine (FAA). BAT results showed an increase of positive results from 37.5% to 62.5% using metamizole plus metabolites as compared with the BAT carried out only with the parent drug, demonstrating that metamizole metabolites have a role in the reaction and can induce specific basophil activation in patients with immediate hypersensitivity to this drug. Our findings indicate that pyrazolone metabolites are useful for improving the in vitro diagnosis of allergic reactions to metamizole.
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