ArticleJournal of virology2016
Two Outbreak Sources of Influenza A (H7N9) Viruses Have Been Established in China.
Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Serological Evidence of Human Infection With Avian Influenza A(H7N9) Virus: A Systematic Review and Meta-analysis.The Journal of infectious diseases · 2022Pooled it
- Virus-induced pathogenesis, vaccine development, and diagnosis of novel H7N9 avian influenza A virus in humans: a systemic literature review.The Journal of international medical research · 2020Pooled it
- Trial
- Trial
- Spatiotemporal distribution trends and driving factors of avian influenza in poultry in China.One health (Amsterdam, Netherlands) · 2026Article
- Neutralizing and protective monoclonal antibodies identify antigenic sites in influenza H7 hemagglutinin and select for amino acid substitutions rarely observed at the global level.Microbiology spectrum · 2026Article
- Influenza strains in focus: global approaches to the diagnosis, treatment, and control of H1N1, H3N2, H7N9, and H9N2.Pathogens and global health · 2025Review
- Review
- Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination.Virulence · 2024Article
- R229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K.Emerging microbes & infections · 2024Article
- Evaluating the epizootic and zoonotic threat of an H7N9 low-pathogenicity avian influenza virus (LPAIV) variant associated with enhanced pathogenicity in turkeys.The Journal of general virology · 2024Article
- Genetically Related Avian Influenza H7N9 Viruses Exhibit Different Pathogenicity in Mice.Animals : an open access journal from MDPI · 2023Article
- Genetic characterization and pathogenicity of H7N9 highly pathogenic avian influenza viruses isolated from South China in 2017.Frontiers in microbiology · 2023Article
- A dominant internal gene cassette of high pathogenicity avian influenza H7N9 virus raised since 2018.Virus genes · 2022Article
- Genome-Wide Reassortment Analysis of Influenza A H7N9 Viruses Circulating in China during 2013-2019.Viruses · 2022Article
- Antigenic Evolution Characteristics and Immunological Evaluation of H9N2 Avian Influenza Viruses from 1994-2019 in China.Viruses · 2022Article
- Ocular manifestations of recent viral pandemics: A literature review.Frontiers in medicine · 2022Review
- Article
- Limited onward transmission potential of reassortment genotypes from chickens co-infected with H9N2 and H7N9 avian influenza viruses.Emerging microbes & infections · 2021Article
- Molecular epidemiologic characteristics of hemagglutinin from five waves of avian influenza A (H7N9) virus infection, from 2013 to 2017, in Zhejiang Province, China.Archives of virology · 2021Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDue to enzootic infections in poultry and persistent human infections in China, influenza A (H7N9) virus has remained a public health threat. The Yangtze River Delta region, which is located in eastern China, is well recognized as the original source for H7N9 outbreaks. Based on the evolutionary analysis of H7N9 viruses from all three outbreak waves since 2013, we identified the Pearl River Delta region as an additional H7N9 outbreak source. H7N9 viruses are repeatedly introduced from these two sources to the other areas, and the persistent circulation of H7N9 viruses occurs in poultry, causing continuous outbreak waves. Poultry movements may contribute to the geographic expansion of the virus. In addition, the AnH1 genotype, which was predominant during wave 1, was replaced by JS537, JS18828, and AnH1887 genotypes during waves 2 and 3. The establishment of a new source and the continuous evolution of the virus hamper the elimination of H7N9 viruses, thus posing a long-term threat of H7N9 infection in humans. Therefore, both surveillance of H7N9 viruses in humans and poultry and supervision of poultry movements should be strengthened. IMPORTANCE: Since its occurrence in humans in eastern China in spring 2013, the avian H7N9 viruses have been demonstrating the continuing pandemic threat posed by the current influenza ecosystem in China. As the viruses are silently circulated in poultry, with potentially severe outcomes in humans, H7N9 virus activity in humans in China is very important to understand. In this study, we identified a newly emerged H7N9 outbreak source in the Pearl River Delta region. Both sources in the Yangtze River Delta region and the Pearl River Delta region have been established and found to be responsible for the H7N9 outbreaks in mainland China.
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