Evidence map›Paper›PMID 27029911›Full record

ArticleEpidemiology and infection2016

Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015.

J Y Wong, W Zhang, D Kargbo, U Haque, W Hu, P Wu, A Kamara, Y Chen, B Kargbo, G E Glass and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Costs and benefits of interventions aimed at major infectious disease threats: lessons from the literature.The European journal of health economics : HEPAC : health economics in prevention and care · 2020
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Preliminary Epidemiologic Assessment of Human Infections With Highly Pathogenic Avian Influenza A(H5N6) Virus, China.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  9. Ebola Virus Disease and Pregnancy: A Retrospective Cohort Study of Patients Managed at 5 Ebola Treatment Units in West Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  10. Observational
  11. Key data for outbreak evaluation: building on the Ebola experience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Review
  12. Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013-2016.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017
    Article
  13. The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014-2015 outbreak in Guinea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Observational
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 5 countries.

J Y WongWHO Collaborating Centre for Infectious Disease Epidemiology and Control,School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
W ZhangBeijing Institute of Disease Control and Prevention,Beijing,China.
D KargboMinistry of Health and Sanitation,Freetown,Sierra Leone.
U HaqueEmerging Pathogens Institute,University of Florida,Gainesville,FL,USA.
W HuSchool of Public Health and Social Work,Queensland University of Technology,Brisbane,Australia.
P WuWHO Collaborating Centre for Infectious Disease Epidemiology and Control,School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
A KamaraMinistry of Health and Sanitation,Freetown,Sierra Leone.
Y ChenBeijing Institute of Disease Control and Prevention,Beijing,China.
B KargboMinistry of Health and Sanitation,Freetown,Sierra Leone.
G E GlassEmerging Pathogens Institute,University of Florida,Gainesville,FL,USA.
R YangChina Mobile Laboratory Response Team for Ebola in Sierra Leone,Freetown,Sierra Leone.
B J CowlingWHO Collaborating Centre for Infectious Disease Epidemiology and Control,School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
C LiuBeijing Institute of Disease Control and Prevention,Beijing,China.
Ministry of Health and Sanitation · SLUniversity of Hong Kong · HKBeijing Center for Disease Prevention and Control · CNUniversity of Florida · USInstitute of Microbiology · CNQueensland University of Technology · AUSierra Leone Urban Research Centre · SL

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in confirmed and probable EVD cases in Sierra Leone. Proportional hazards regression models were used to investigate factors associated with the risk of death in EVD cases. In total, there were 17 318 EVD cases reported in Sierra Leone from 23 May 2014 to 31 January 2015. Of the probable and confirmed EVD cases with a reported final outcome, a total of 2536 deaths and 886 recoveries were reported. CFR and HFR estimates were 74·2% [95% credibility interval (CrI) 72·6-75·5] and 68·9% (95% CrI 66·2-71·6), respectively. Risks of death were higher in the youngest (0-4 years) and oldest (⩾60 years) age groups, and in the calendar month of October 2014. Sex and occupational status did not significantly affect the mortality of EVD. The CFR and HFR estimates of EVD were very high in Sierra Leone.

Indexed as

EpidemicsSeverity of Illness IndexAdolescentAdultAgedAged, 80 and overChildChild, PreschoolEbolavirusFemaleHemorrhagic Fever, EbolaHospitalizationHumansInfantInfant, NewbornMaleDeathEbola virusseverity

Identifiers

PMID27029911
PMCPMC5528867
OpenAlexW2280753055

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.