ReviewAddiction biology2016
Why we should consider sex (and study sex differences) in addiction research.
Review in Addiction biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Good Practice Guideline for Preclinical Alcohol Research: The STRINGENCY Framework.Current topics in behavioral neurosciences · 2025Guideline
- Fatty Acid-Binding Proteins and Substance Use Disorders: From Lipid Signaling to Therapeutic Targets.Genes · 2026Review
- Sex-specific neural responses to smartphone cues in young adults.Biology of sex differences · 2026Article
- The impact of sex, species, environmental context, and alternative reinforcers in animal models of cocaine use disorders.Pharmacology, biochemistry, and behavior · 2025Review
- The relationship between personality dimensions and addiction type in women addicted to alcohol and opioids.Scientific reports · 2025Article
- Prevalence of food addiction and sex-specific correlates in a large sample of Iranian adults.Scientific reports · 2025Article
- Assessment of abuse potential of furanylfentanyl and tetrahydrofuranylfentanyl.Psychopharmacology · 2025Article
- A new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Sex Differences in Neural Circuits Underlying Fear Processing.Current topics in behavioral neurosciences · 2025Review
- Association Study of Serotonin 1A Receptor Gene, Personality, and Anxiety in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024Article
- Subregion specific neuroadaptations in the female rat striatum during acute and protracted withdrawal from nicotine.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Article
- Prelimbic Cortex Activity during a Distress Tolerance Task Predicts Cocaine-Seeking Behavior in Male, But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Relationship between Depression and Cognitive Inhibition in Men with Heroin or Methamphetamine Use Disorder in First-Time Mandatory Detoxification.Healthcare (Basel, Switzerland) · 2022Article
- Teaching About Sex and Gender in Neuroscience: More Than Meets the "XY".Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2022Article
- Barriers to Accessing Addiction Treatment for Women at Risk of Homelessness.Frontiers in global women's health · 2022Article
- Binge drinking indirectly predicts a negative emotional memory bias through coping motivations and depressive symptoms: The role of sex/gender.Frontiers in psychology · 2022Article
- mGlu2 mechanism-based interventions to treat alcohol relapse.Frontiers in pharmacology · 2022Article
- Post-legalization changes in marijuana use in a sample of young California adults.Addictive behaviors · 2021Article
- Female mice are more prone to develop an addictive-like phenotype for sugar consumption.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Among mammals, every cell has a biological sex, and the sex of an individual pervades its body and brain. In this review, we describe the processes through which mammals become phenotypically male or female by organizational and activational influences of genes and hormones throughout development. We emphasized that the molecular and cellular changes triggered by sex chromosomes and steroid hormones may generate sex differences in overt physiological functions and behavior, but they may alternatively promote end-point convergences between males and females. Clinical and pre-clinical evidences suggest that sex and gender differences modulate drug consumption as well as of the transition towards drug-promoted pathological states such as dependence and addiction. Additionally, sex differences in drug pharmacokinetics and pharmacodynamics will also influence dependence and addiction as well as side effects of drugs. These effects will further interact with socially gendered factors to result in sex differences in the access to, engagement in and efficacy of any therapeutic attempt. Finally, we maintain that 'sex sameness' is as important as 'sex differences' when building a complete understanding of biology for both males and females and provide a framework with which to classify and guide investigation into the mechanisms mediating sex differences and sex sameness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.