ArticleScientific reports2016
Anatomical and functional gonadotrope networks in the teleost pituitary.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Recent Advances in the Understanding of Gonadotrope Lineage Differentiation in the Developing Pituitary.Neuroendocrinology · 2025Review
- The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.eLife · 2024Article
- Characterization of a novel fast-growing zebrafish: a new approach to growth hormone transgenesis.Frontiers in endocrinology · 2024Article
- Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status.PloS one · 2022Article
- Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon:Frontiers in endocrinology · 2022Article
- Characterization of hormone-producing cell types in the teleost pituitary gland using single-cell RNA-seq.Scientific data · 2021Article
- Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary.International journal of molecular sciences · 2021Article
- Long extensions with varicosity-like structures in gonadotrope Lh cells facilitate clustering in medaka pituitary culture.PloS one · 2021Article
- Functional Pituitary Networks in Vertebrates.Frontiers in endocrinology · 2020Review
- From Pituitary Stem Cell Differentiation to Regenerative Medicine.Frontiers in endocrinology · 2020Review
- Spexin and a Novel Cichlid-Specific Spexin Paralog Both Inhibit FSH and LH Through a Specific Galanin Receptor (Galr2b) in Tilapia.Frontiers in endocrinology · 2020Article
- Ontogeny of the specificity of gonadotropin receptors and gene expression in carp.Endocrine connections · 2019Article
- Article
- Progestin increases the expression of gonadotropins in pituitaries of male zebrafish.The Journal of endocrinology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian pituitaries exhibit a high degree of intercellular coordination; this enables them to mount large-scale coordinated responses to various physiological stimuli. This type of communication has not been adequately demonstrated in teleost pituitaries, which exhibit direct hypothalamic innervation and expression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in distinct cell types. We found that in two fish species, namely tilapia and zebrafish, LH cells exhibit close cell-cell contacts and form a continuous network throughout the gland. FSH cells were more loosely distributed but maintained some degree of cell-cell contact by virtue of cytoplasmic processes. These anatomical differences also manifest themselves at the functional level as evidenced by the effect of gap-junction uncouplers on gonadotropin release. These substances abolished the LH response to gonadotropin-releasing hormone stimulation but did not affect the FSH response to the same stimuli. Dye transfer between neighboring LH cells provides further evidence for functional coupling. The two gonadotropins were also found to be differently packaged within their corresponding cell types. Our findings highlight the evolutionary origin of pituitary cell networks and demonstrate how the different levels of cell-cell coordination within the LH and FSH cell populations are reflected in their distinct secretion patterns.
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