ArticleScientific reports2016
Sex reversal assessments reveal different vulnerability to endocrine disruption between deeply diverged anuran lineages.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- Uncovering the transcriptional landscape of estrogen-induced gonadal feminization in the Chinese giant salamander.BMC genomics · 2026Article
- Pregametogenesis: The Earliest Stages of Gonad and Germline Differentiation in Anuran Amphibians.Biology · 2024Review
- A candidate sex determination locus in amphibians which evolved by structural variation between X- and Y-chromosomes.Nature communications · 2024Article
- Endocrine disruption in teleosts and amphibians is mediated by anthropogenic and natural environmental factors: implications for risk assessment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Temporal and spatial variations in local sex ratios in a suburban population of the European green toad Bufotes viridis.BMC ecology and evolution · 2023Article
- Novel genetic sex markers reveal unexpected lack of, and similar susceptibility to, sex reversal in free-living common toads in both natural and anthropogenic habitats.Molecular ecology · 2022Article
- Using Sex-Linked Markers via Genotyping-by-Sequencing to Identify XX/XY Sex Chromosomes in the Spiny Frog (Genes · 2022Article
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Analyzing the gonadal transcriptome of the frog Hoplobatrachus rugulosus to identify genes involved in sex development.BMC genomics · 2021Article
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- Genomic Data Reveal Conserved Female Heterogamety in Giant Salamanders with Gigantic Nuclear Genomes.G3 (Bethesda, Md.) · 2019Article
- Impacts of the synthetic androgen Trenbolone on gonad differentiation and development - comparisons between three deeply diverged anuran families.Scientific reports · 2019Article
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- Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles.EFSA journal. European Food Safety Authority · 2018Article
- Demographic and genetic consequences of disturbed sex determination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Climate-driven shifts in adult sex ratios via sex reversals: the type of sex determination matters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Chronic exposures to fungicide pyrimethanil: multi-organ effects on Italian tree frog (Hyla intermedia).Scientific reports · 2017Article
- Sex-linked markers in the North American green frog (Rana clamitans) developed using DArTseq provide early insight into sex chromosome evolution.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple anthropogenic stressors cause worldwide amphibian declines. Among several poorly investigated causes is global pollution of aquatic ecosystems with endocrine disrupting compounds (EDCs). These substances interfere with the endocrine system and can affect the sexual development of vertebrates including amphibians. We test the susceptibility to an environmentally relevant contraceptive, the artificial estrogen 17α-ethinylestradiol (EE2), simultaneously in three deeply divergent systematic anuran families, a model-species, Xenopus laevis (Pipidae), and two non-models, Hyla arborea (Hylidae) and Bufo viridis (Bufonidae). Our new approach combines synchronized tadpole exposure to three EE2-concentrations (50, 500, 5,000 ng/L) in a flow-through-system and pioneers genetic and histological sexing of metamorphs in non-model anurans for EDC-studies. This novel methodology reveals striking quantitative differences in genetic-male-to-phenotypic-female sex reversal in non-model vs. model species. Our findings qualify molecular sexing in EDC-analyses as requirement to identify sex reversals and state-of-the-art approaches as mandatory to detect species-specific vulnerabilities to EDCs in amphibians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.