ReviewAntibiotics (Basel, Switzerland)2013
Phenotypic Resistance to Antibiotics.
Review in Antibiotics (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 204 citations in OpenAlex.
- Phenotypic and genotypic landscape of antibiotic resistance through One Health approach in Sri Lanka: A systematic review.Tropical medicine & international health : TM & IH · 2025Pooled it
- Sequence of Antibiotic Administration for the Treatment ofAntibiotics (Basel, Switzerland) · 2026Article
- Evaluating long-read metagenomics for bloodstream infection diagnostics: a pilot study from a Thai Tertiary Hospital.Scientific reports · 2026Article
- Presence of antimicrobial resistance genes in biofilms from swine drinking water pipes before and after treatment with peracetic acid.Frontiers in microbiology · 2026Article
- Article
- Resisting the gallium "Trojan horse": Experimental evolutionary insights into microbial resistance.Gene & protein in disease · 2026Article
- Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials inAntimicrobial agents and chemotherapy · 2025Article
- Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics.Microbial genomics · 2025Article
- Combining Phenotypic and Genotypic Methods for the Rapid Detection of Antibiotic-Resistant Bacteria in Wastewater Using a Microfluidic Centrifugal Disc.ACS ES&T engineering · 2025Article
- Comamonas resistens Co-Producing GES-5 and OXA-17 in Urban Wastewater as a Potential Novel Disseminator of Clinically Relevant β-Lactamases.Current microbiology · 2025Article
- Genomic characterization of antimicrobial resistance and mobile genetic elements in swine gut bacteria isolated from a Canadian research farm.Animal microbiome · 2025Article
- Antibiotic resistance and preventive strategies in foodborne pathogenic bacteria: a comprehensive review.Food science and biotechnology · 2025Review
- Impact of an antimicrobial time-out program on antimicrobial consumption rate in hospitalized patients: a quasi-experimental study on the national antimicrobial stewardship program in Iran : Iranian antimicrobial stewardship program.Journal of pharmaceutical health care and sciences · 2025Article
- The evaluation of antimicrobial resistance rates in infections caused by uropathogenicIranian journal of microbiology · 2025Article
- Dual-Functional Antibiotic Adjuvant Displays Potency against Complicated Gram-Negative Bacterial Infections and Exhibits Immunomodulatory Properties.ACS central science · 2025Article
- Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events.npj antimicrobials and resistance · 2025Article
- The Role of the Hfq Protein in Bacterial Resistance to Antibiotics: A Narrative Review.Microorganisms · 2025Review
- Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics.bioRxiv : the preprint server for biology · 2025Article
- Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings.Antibiotics (Basel, Switzerland) · 2025Review
- Magnesium modulates phospholipid metabolism to promote bacterial phenotypic resistance to antibiotics.eLife · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of antibiotic resistance is usually associated with genetic changes, either to the acquisition of resistance genes, or to mutations in elements relevant for the activity of the antibiotic. However, in some situations resistance can be achieved without any genetic alteration; this is called phenotypic resistance. Non-inherited resistance is associated to specific processes such as growth in biofilms, a stationary growth phase or persistence. These situations might occur during infection but they are not usually considered in classical susceptibility tests at the clinical microbiology laboratories. Recent work has also shown that the susceptibility to antibiotics is highly dependent on the bacterial metabolism and that global metabolic regulators can modulate this phenotype. This modulation includes situations in which bacteria can be more resistant or more susceptible to antibiotics. Understanding these processes will thus help in establishing novel therapeutic approaches based on the actual susceptibility shown by bacteria during infection, which might differ from that determined in the laboratory. In this review, we discuss different examples of phenotypic resistance and the mechanisms that regulate the crosstalk between bacterial metabolism and the susceptibility to antibiotics. Finally, information on strategies currently under development for diminishing the phenotypic resistance to antibiotics of bacterial pathogens is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.