ArticleBMC neuroscience2016
Neuroanatomical features in soldiers with post-traumatic stress disorder.
Article in BMC neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia.Biological psychiatry · 2018Pooled it
- Electrophysiological Markers of Proactive and Reactive Cognitive Processing in Post-Traumatic Stress Disorder.Brain sciences · 2026Article
- Differences in Brain Structure and Functional Connectivity During Memory Processing in Posttraumatic Stress Disorder.Psychiatry investigation · 2026Article
- Lower right insular thickness is associated with more severe post-traumatic stress disorder symptoms among Ukrainian refugees.Frontiers in psychiatry · 2026Article
- Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia.Translational psychiatry · 2025Article
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Neuroimaging in post-traumatic stress disorder: a narrative review.Archives of medical science : AMS · 2025Article
- Weaker situations: Uncertainty reveals individual differences in learning: Implications for PTSD.Cognitive, affective & behavioral neuroscience · 2023Review
- Inflammatory Markers and Brain Volume in Patients with Post-traumatic Stress Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review.Frontiers in systems neuroscience · 2023Review
- Reexperiencing and anxious arousal symptoms in relation to volumes of thalamus nuclei in posttraumatic stress spectrum adults.Brain and behavior · 2022Article
- The cerebellum and psychological trauma: A systematic review of neuroimaging studies.Neurobiology of stress · 2022Review
- Acute-stress-induced change in salience network coupling prospectively predicts post-trauma symptom development.Translational psychiatry · 2022Article
- Increased medial prefrontal cortical thickness and resilience to traumatic experiences in North Korean refugees.Scientific reports · 2021Article
- Neural response to trauma-related and trauma-unrelated negative stimuli in remitted and persistent pediatric post-traumatic stress disorder.Brain and behavior · 2021Article
- The Role of the Thalamus in Post-Traumatic Stress Disorder.International journal of molecular sciences · 2021Review
- Multimodal MRI Assessment of Thalamic Structural Changes in Earthquake Survivors.Diagnostics (Basel, Switzerland) · 2021Article
- Reduced gray matter volume in the left prefrontal, occipital, and temporal regions as predictors for posttraumatic stress disorder: a voxel-based morphometric study.European archives of psychiatry and clinical neuroscience · 2020Article
- Cortical Thickness in Dutch Police Officers: An Examination of Factors Associated with Resilience.Journal of traumatic stress · 2020Article
- DisConICA: a Software Package for Assessing Reproducibility of Brain Networks and their Discriminability across Disorders.Neuroinformatics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosttraumatic stress disorder (PTSD), an anxiety disorder that can develop after exposure to psychological trauma, impacts up to 20 % of soldiers returning from combat-related deployment. Advanced neuroimaging holds diagnostic and prognostic potential for furthering our understanding of its etiology. Previous imaging studies on combat-related PTSD have focused on selected structures, such as the hippocampi and cortex, but none conducted a comprehensive examination of both the cerebrum and cerebellum. The present study provides a complete analysis of cortical, subcortical, and cerebellar anatomy in a single cohort. Forty-seven magnetic resonance images (MRIs) were collected from 24 soldiers with PTSD and 23 Control soldiers. Each image was segmented into 78 cortical brain regions and 81,924 vertices using the corticometric iterative vertex based estimation of thickness algorithm, allowing for both a region-based and a vertex-based cortical analysis, respectively. Subcortical volumetric analyses of the hippocampi, cerebellum, thalamus, globus pallidus, caudate, putamen, and many sub-regions were conducted following their segmentation using Multiple Automatically Generated Templates Brain algorithm.
resultsParticipants with PTSD were found to have reduced cortical thickness, primarily in the frontal and temporal lobes, with no preference for laterality. The region-based analyses further revealed localized thinning as well as thickening in several sub-regions. These results were accompanied by decreased volumes of the caudate and right hippocampus, as computed relative to total cerebral volume. Enlargement in several cerebellar lobules (relative to total cerebellar volume) was also observed in the PTSD group.
conclusionsThese data highlight the distributed structural differences between soldiers with and without PTSD, and emphasize the diagnostic potential of high-resolution MRI.
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