Evidence map›Paper›PMID 27028998›Full record

ArticleOncotarget2016

Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer.

Zijun Xie, Xiaoliang Chen, Jianzhong Li, Yunwei Guo, Haijiao Li, Xuemei Pan, Jie Jiang, Huiling Liu, Bin Wu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 147 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Challenges of early detection of pancreatic cancer.The Journal of clinical investigation · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zijun XieDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiaoliang ChenDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Jianzhong LiDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Yunwei GuoDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Haijiao LiDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xuemei PanDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Jie JiangDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Huiling LiuDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Bin WuDepartment of Gastroenterology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Third Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sensitive and non-invasive biomarkers for pancreatic cancer (PC) are lacking. We aimed to identify salivary long non-coding RNAs (lncRNAs) as biomarkers in diagnosis of resectable PC. Five well-documented lncRNAs: H19, HOTAIR, HOTTIP, MALAT1, PVT1, which are most closely associated with pancreatic cancer from previous studies were selected as putative lncRNA biomarkers. Their expression in pancreatic tissues and saliva of cancer patients and healthy controls was measured by quantification polymerase chain reaction (qPCR). Compared with benign pancreatic tumour (BPT) and normal pancreatic tissues (NPT), HOTAIR, HOTTIP and PVT1 were significantly up-regulated in pancreatic cancer tissues (PCT). As compared to BPT or healthy groups, the salivary levels of HOTAIR and PVT1 were significantly higher in PC group. They were significantly reduced after the curative pancreatectomy. Both salivary lncRNAs distinguished PC patients from healthy controls and BPT patients with sensitivities and specificities ranging from 60-97%. The expression of salivary HOTAIR and PVT1 did not differ significantly between healthy controls and any one of eight leading cancers worldwide. Collectively, our findings indicate that salivary HOTAIR and PVT1 show potential as novel non-invasive biomarkers for detecting PC.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinomaEarly Detection of CancerFemaleHumansMaleMicroRNAsMiddle AgedPancreatic NeoplasmsRNA, Long NoncodingSalivaSensitivity and SpecificityUp-RegulationBiomarkers, Tumorlong non-coding RNA HOTAIRM1, humanMicroRNAsPVT1 long-non-coding RNA, humanRNA, Long NoncodingbiomarkerdiagnosisHOTAIRpancreatic cancerPVT1

Identifiers

PMID27028998
PMCPMC5041913
OpenAlexW2309684261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.