Evidence map›Paper›PMID 27028990›Full record

ReviewRespirology (Carlton, Vic.)2016

Acute exacerbation of COPD.

Fanny W Ko, Ka Pang Chan, David S Hui, John R Goddard, Janet G Shaw, David W Reid, Ian A Yang

5 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Respirology (Carlton, Vic.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 207 papers, 24 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 24 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03584269 naterminatednot on this mapstarted 2018, after this paper: background citation

Non Invasive Ventilation and Nocturnal Alveolar Hypoventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) Treated by Long Term Oxygen Therapy at Home

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2018 to 2019Enrolled45ConditionsChronic Obstructive Pulmonary DiseaseArmsNIV Device + LTOT, LTOT
NCT03851991 phase4completednot on this mapstarted 2019, after this paper: background citation

A 52-week Multicenter, Randomized, Double-blind, Placebo-controlled, Prospective Study to Evaluate the Efficacy and Safety of Arbidol in Reducing the Frequency of AECOPD.

TypeinterventionalSponsorShengjing HospitalRan2019 to 2024Enrolled351ConditionsCOPD PatientsArmsArbidol, Placebos
NCT05587829 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Diaphragm and Abdominal Muscle Training on Pulmonary Function Testing and Dyspnea Among Chronic Obstructive Pulmonary Disease Patients.

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled50ConditionsChronic Obstructive Pulmonary DiseaseArms• Diaphragmatic breathing technique, basic breathing technique
NCT05906264 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of Compliance and Effectiveness of Pulmonary Rehabilitation Program in COPD Patient

TypeinterventionalSponsorSamsung Medical CenterRan2022 to 2025Enrolled64ConditionsChronic Obstructive Pulmonary DiseaseArmsTele-intervention
NCT06143150 not yet recruitingnot on this mapstarted 2023, after this paper: background citation

Can Transthoracic Ultrasound Assessment of the Diaphragmatic Performance Predict the Outcome of Non Invasive Ventilation in Critically Ill COPD Patients With Acute Exacerbation

TypeobservationalSponsorAssiut UniversityRan2023 to 2027Enrolled155ConditionsAcute Exacerbation COPDArmstransthoracic ultrasound
3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 24 syntheses or guidelines pooled it, 346 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Predictors of Acute Exacerbations in COPD: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2026
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Pooled it
  17. Pooled it
  18. Pooled it
  19. Pooled it
  20. NT-proBNP in Different Patient Groups of COPD: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2023
    Pooled it

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Fanny W KoDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong. fannyko@cuhk.edu.hk.
Ka Pang ChanDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0002-8163-5846
David S HuiDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.
John R GoddardSchool of Medicine, The University of Queensland, Brisbane, Australia.
Janet G ShawSchool of Medicine, The University of Queensland, Brisbane, Australia.
David W ReidSchool of Medicine, The University of Queensland, Brisbane, Australia.
Ian A YangSchool of Medicine, The University of Queensland, Brisbane, Australia.
The University of Queensland · AUChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The literature of acute exacerbation of chronic obstructive pulmonary disease (COPD) is fast expanding. This review focuses on several aspects of acute exacerbation of COPD (AECOPD) including epidemiology, diagnosis and management. COPD poses a major health and economic burden in the Asia-Pacific region, as it does worldwide. Triggering factors of AECOPD include infectious (bacteria and viruses) and environmental (air pollution and meteorological effect) factors. Disruption in the dynamic balance between the 'pathogens' (viral and bacterial) and the normal bacterial communities that constitute the lung microbiome likely contributes to the risk of exacerbations. The diagnostic approach to AECOPD varies based on the clinical setting and severity of the exacerbation. After history and examination, a number of investigations may be useful, including oximetry, sputum culture, chest X-ray and blood tests for inflammatory markers. Arterial blood gases should be considered in severe exacerbations, to characterize respiratory failure. Depending on the severity, the acute management of AECOPD involves use of bronchodilators, steroids, antibiotics, oxygen and noninvasive ventilation. Hospitalization may be required, for severe exacerbations. Nonpharmacological interventions including disease-specific self-management, pulmonary rehabilitation, early medical follow-up, home visits by respiratory health workers, integrated programmes and telehealth-assisted hospital at home have been studied during hospitalization and shortly after discharge in patients who have had a recent AECOPD. Pharmacological approaches to reducing risk of future exacerbations include long-acting bronchodilators, inhaled steroids, mucolytics, vaccinations and long-term macrolides. Further studies are needed to assess the cost-effectiveness of these interventions in preventing COPD exacerbations.

Indexed as

Pulmonary Disease, Chronic ObstructiveSymptom Flare UpDisease ManagementHumansaetiologychronic obstructive pulmonary diseasediagnosisexacerbationintervention

Identifiers

PMID27028990
PMCPMC7169165
OpenAlexW2314900475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.