Evidence map›Paper›PMID 27028860›Full record

ArticleOncotarget2016

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Yun Teng, Jingyao Mu, Xin Hu, Abhilash Samykutty, Xiaoying Zhuang, Zhongbin Deng, Lifeng Zhang, Pengxiao Cao, Jun Yan, Donald Miller and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 127 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yun TengJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Jingyao MuJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Xin HuProgram in Biostatistics, Bioinformatics and Systems Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
Abhilash SamykuttyJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Xiaoying ZhuangJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Zhongbin DengJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Lifeng ZhangJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Pengxiao CaoJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Jun YanJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Donald MillerJames Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Huang-Ge ZhangRobley Rex VA Medical Center, Louisville, KY 40206, USA.
University of Louisville · USJames Graham Brown Foundation · USThe University of Texas MD Anderson Cancer Center · US

Funding

Plant exosomes non-coding RNA-mediated anti-inflammatory mechanismsR01AT008617 · NCCIH · UNIVERSITY OF LOUISVILLE · PI HUANG-GE ZHANG · 2016 to 2026
$5.7M
Fruit exosome-like particles for therapeutic delivery of extracellular miRNAsUH3TR000875 · NCATS · UNIVERSITY OF LOUISVILLE · PI ZHANG, HUANG-GE · 2015 to 2017
$2.7M
Exosomal TRAF2-CSN5 complex mediated inflammation promotes tumor growthI01BX000962 · VA · LOUISVILLE VA MEDICAL MEDICAL CENTER · PI ZHANG, HUANG-GE · 2011 to 2014
–
BLRD VA I01 BX000962NCATS NIH HHS UH3 TR000875NCCIH NIH HHS R01 AT008617
6 · The paper itself

Abstract

Liver metastasis accounts for many of the cancer deaths in patients. Effective treatment for metastatic liver tumors is not available. Here, we provide evidence for the role of miR-18a in the induction of liver M1 (F4/80+interferon gamma (IFNγ)+IL-12+) macrophages. We found that miR-18a encapsulated in grapefruit-derived nanovector (GNV) mediated inhibition of liver metastasis that is dependent upon the induction of M1 (F4/80+IFNγ+IL-12+) macrophages; depletion of macrophages eliminated its anti-metastasis effect. Furthermore, the miR-18a mediated induction of macrophage IFNγ by targeting IRF2 is required for subsequent induction of IL-12. IL-12 then activates natural killer (NK) and natural killer T (NKT) cells for inhibition of liver metastasis of colon cancer. This conclusion is supported by the fact that knockout of IFNγ eliminates miR-18a mediated induction of IL-12, miR-18a treatment has an anti-metastatic effects in T cell deficient mice but there is no anti-metastatic effect on NK and NKT deficient mice. Co-delivery of miR-18a and siRNA IL-12 to macrophages did not result in activation of co-cultured NK and NKT cells. Taken together our results indicate that miR-18a can act as an inhibitor for liver metastasis through induction of M1 macrophages.

Indexed as

Citrus paradisiAnimalsColonic NeoplasmsGenetic TherapyGenetic VectorsLipidsLiver NeoplasmsMacrophage ActivationMacrophagesMiceMicroRNAsNanoparticlesPlant ExtractsLipidsMicroRNAsPlant Extractsgrapefruit-derived nanovectorIRF2liver metastasis of colon cancerM1 Kupffer cellsmiR-18a

Identifiers

PMID27028860
PMCPMC5041936
OpenAlexW2314704003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.