ArticleContrast media & molecular imaging2016
Evaluation of Eu(II) -based positive contrast enhancement after intravenous, intraperitoneal, and subcutaneous injections.
Article in Contrast media & molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Cyclen Tetra-Amide Ligands as a Privileged Class of Ligands for Studying Second-Sphere Coordination Environments.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Single Molecule EuJournal of the American Chemical Society · 2026Article
- Controlling the Kinetic and Electrochemical Properties of EuInorganic chemistry · 2026Article
- Solution-Phase Electrochemical Characterization of Acyclic Complexes of Divalent Europium.Inorganic chemistry · 2026Article
- Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025Article
- Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia.Advanced healthcare materials · 2023Article
- Toward quantification of hypoxia using fluorinated EuProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Systemic Delivery of Divalent Europium from Ligand Screening with Implications to Direct Imaging of Hypoxia.Journal of the American Chemical Society · 2022Article
- Intraperitoneal administration for sustained photoacoustic contrast agent imaging.Photoacoustics · 2022Article
- Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions.Biosensors · 2022Review
- Rational Design of High-Relaxivity EuChemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Measurement of the Dissociation of EuInorganic chemistry · 2020Article
- Molecular Magnetic Resonance Imaging Using a Redox-Active Iron Complex.Journal of the American Chemical Society · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Screening of ligands for redox-active europium using magnetic resonance imaging.Bioorganic & medicinal chemistry · 2018Article
- Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure-Activity Relationships and Lead Candidate Evaluation.Journal of medicinal chemistry · 2018Article
- Synthesis, Characterization, and Handling of EuFrontiers in chemistry · 2018Review
- Fluorinated EuChemical science · 2017Article
- Electrochemical investigation of the EuEuropean journal of inorganic chemistry · 2017Article
- Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Eu(II) -based contrast agents offer physiologically relevant, metal-based redox sensing that is unachievable with Gd(III) -based contrast agents. To evaluate the in vivo contrast enhancement of Eu(II) as a function of injection type, we performed intravenous, intraperitoneal, and subcutaneous injections in mice. Our data reveal a correlation between reported oxygen content and expected rates of diffusion with the persistence of Eu(II) -based contrast enhancement. Biodistribution studies revealed europium clearance through the liver and kidneys for intravenous and intraperitoneal injections, but no contrast enhancement was observed in organs associated with clearance. These data represent a step toward understanding the behavior of Eu(II) -based complexes in vivo. Copyright © 2016 John Wiley & Sons, Ltd.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.