Evidence map›Paper›PMID 27028397›Full record

ArticleTropical medicine & international health : TM & IH2016

Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices.

Ahmed A Daak, Elfatih Elsamani, Eltigani H Ali, Fatma A Mohamed, Manar E Abdel-Rahman, Abozer Y Elderdery, Octavious Talbot, Peter Kraft, Kebreab Ghebremeskel, Mustafa I Elbashir and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in Tropical medicine & international health : TM & IH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 63 citations in OpenAlex.

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  19. Molecular Analysis of Xmn1-Polymorphic Site ´5 to GEvidence-based complementary and alternative medicine : eCAM · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Ahmed A DaakDepartment of Global Health and Population, Harvard University, Boston, MA, USA.
Elfatih ElsamaniDepartment of Community Medicine, School of Medicine, Ahfad University for Women, Khartoum, Sudan.
Eltigani H AliLipidomics and Nutrition Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK.
Fatma A MohamedSchool of Nursing Sciences, University of Khartoum, Khartoum, Sudan.
Manar E Abdel-RahmanDepartment of Statistics, Faculty of Mathematical Sciences, University of Khartoum, Khartoum, Sudan.
Abozer Y ElderderySchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Octavious TalbotDepartment of Biostatistics, Harvard University, Boston, MA, USA.
Peter KraftDepartment of Biostatistics, Harvard University, Boston, MA, USA.
Kebreab GhebremeskelLipidomics and Nutrition Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, UK.
Mustafa I ElbashirDepartment of Medical Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Wafaie FawziDepartment of Global Health and Population, Harvard University, Boston, MA, USA.
Harvard University · USUniversity of Khartoum · SDLondon Metropolitan University · GBAhfad University for Women · SDHarvard Global Health Institute · USUniversity of Portsmouth · GB

Funding

BIOSTATISTICS/EPIDEMIOLOGY TRAINING GRANTS IN AIDST32AI007358 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Michael David Hughes · 1989 to 2026
$12.4M
NIAID NIH HHS T32 AI007358
6 · The paper itself

Abstract

objectiveTo investigate the epidemiology of sickle cell disease (SCD) and determinants of knowledge, attitudes and practices (KAP) towards SCD in western Kordofan State, Sudan.

methodsA community-based, descriptive, cross-sectional study was conducted in three towns. Three hundred and seventy-two households were polled, and blood samples for haemoglobin phenotyping were collected from 1116 individuals. Sociodemographic, socio-economic and KAP data were collected using investigator-administered questionnaires. Descriptive, frequency distribution and multiple regression analyses were performed.

resultsAbout 50.9% of the study population were Misseriya tribes. Consanguineous marriages were reported by 67.5% of the households. The highest percentage of homozygous SCD was 2.8% among children under 5 years of age. About 24.9% were carriers of HbS allele (HbAS). HbS allele frequency was highest in children aged 5-11 years (18.3%, CI: 13.7-22.9%) and lowest in males >15 years old (12.0%, CI: 6.1-17.9%). The average HbS frequency across all age groups was 14.5% (95% CI: 12.2-16.8%). The most frequent β-globin gene cluster haplotype was the Cameroon (30.8%), followed by the Benin (21.8%), the Senegal (12.8%) and the Bantu (2.2%) haplotypes. About 17.0% of all-cause child deaths were due to SCD. The estimated change in log odds of having the SS genotype per year increase in age was (-) 0.0058 (95% CI -0.0359, 0.0242). This represents a non-statistically significant 2.9% increase in 5-year mortality for individuals with the SS genotype relative to those with AS and AA genotypes. About 46.9% of the households had poor knowledge, 26.1% had satisfactory knowledge, and 26.9% had good knowledge about sickle cell disease. Mothers' and fathers' educational levels were significant predictors of good knowledge about SCD (P < 0.05). About 48.0% had a satisfactory attitude towards sickle cell disease while 30.7% had poor attitude and only 21.3 showed good attitudes. Poor knowledge about SCD and low socio-economic status were the strongest positive predictors of poor attitude and practices towards SCD (P < 0.01).

conclusionsSickle cell disease is a major health problem in West Kordofan, Sudan. Knowledge, attitude and practices towards the disease are not satisfactory. The development of public health programs is highly recommended to control and manage SCD in western parts of Sudan.

Indexed as

Health Knowledge, Attitudes, PracticeMolecular EpidemiologyAdolescentAdultAge DistributionAnemia, Sickle CellBlood Cell CountCause of DeathChildChild MortalityChild, PreschoolCluster AnalysisEducational StatusFemaleHaplotypesHumansactitudes y prácticas (CAP)Anemia falciformeattitudes et pratiques (CAP)connaissancesconocimientosdrépanocytoseepidemiología genéticaépidémiologie génétiquegenetic epidemiologyhaplotiposhaplotypesknowledge attitude and practicesouest du Soudansickle cell diseaseSudán Occidentalwestern Sudan

Identifiers

PMID27028397
PMCPMC10699227
OpenAlexW2318375484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.