ArticlePloS one2016
Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cholinergic network modulation in disinhibited eating behavior.Communications biology · 2025Article
- About Sugar Addiction.Brain and behavior · 2025Review
- The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors.Frontiers in immunology · 2025Article
- Moving Forward to Disentangle the Role of the Brain in Human Obesity.Brain sciences · 2024Article
- The potential effect of α7 nicotinic receptors modulation on palatable food-induced dependence-like behaviors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.Nutrients · 2022Review
- Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards.Neuroscience · 2022Article
- Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice.Frontiers in molecular neuroscience · 2021Article
- Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood.Frontiers in neuroscience · 2021Article
- The role of nicotinic acetylcholine receptors in alcohol-related behaviors.Brain research bulletin · 2020Review
- Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models.Current topics in behavioral neurosciences · 2020Article
- The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption.Neuropharmacology · 2018Article
- Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens.Brain sciences · 2018Article
- Varenicline modulates ethanol and saccharin consumption in adolescent male and female C57BL/6J mice.Brain research bulletin · 2018Article
- Effects of nicotine on homeostatic and hedonic components of food intake.The Journal of endocrinology · 2017Review
- Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice.Brain and behavior · 2017Article
- α6β2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.Alcohol (Fayetteville, N.Y.) · 2017Article
- Article
- A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption.Frontiers in behavioral neuroscience · 2017Article
- Prolonged Consumption of Sucrose in a Binge-Like Manner, Alters the Morphology of Medium Spiny Neurons in the Nucleus Accumbens Shell.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate dopamine levels in the nucleus accumbens (NAc), in the mesolimbic reward pathway of the brain similar to many drugs of abuse. We report that varenicline, an FDA-approved nicotinic acetylcholine receptor (nAChR) partial agonist that modulates dopamine in the mesolimbic reward pathway of the brain, significantly reduces sucrose consumption, especially in a long-term consumption paradigm. Similar results were observed with other nAChR drugs, namely mecamylamine and cytisine. Furthermore, we show that long-term sucrose consumption increases α4β2 * and decreases α6β2* nAChRs in the nucleus accumbens, a key brain region associated with reward. Taken together, our results suggest that nAChR drugs such as varenicline may represent a novel treatment strategy for reducing sugar consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.