Evidence map›Paper›PMID 27028280›Full record

ReviewObesity (Silver Spring, Md.)2016

Common scientific and statistical errors in obesity research.

Brandon J George, T Mark Beasley, Andrew W Brown, John Dawson, Rositsa Dimova, Jasmin Divers, TaShauna U Goldsby, Moonseong Heo, Kathryn A Kaiser, Scott W Keith and 7 more

Abstract readReview
In one paragraph

Review in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Claims of sex-dependent effects in the behavioral and brain sciences are infrequently supported by valid statistical comparisons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Causal models and causal modelling in obesity: foundations, methods and evidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  16. Why and How to Account for Sex and Gender in Brain and Behavioral Research.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Brandon J GeorgeOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
T Mark BeasleyDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Andrew W BrownOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
John DawsonDepartment of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA.
Rositsa DimovaDepartment of Biostatistics, University at Buffalo, Buffalo, New York, USA.
Jasmin DiversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
TaShauna U GoldsbyOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Moonseong HeoDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Kathryn A KaiserOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Scott W KeithDivision of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Mimi Y KimDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Peng LiOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tapan MehtaNutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Michael OakesDepartment of Epidemiology & Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Asheley SkinnerDepartment of Health Policy and Management, University of North Carolina, Chapel Hill, North Carolina, USA.
Elizabeth StuartDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
David B AllisonOffice of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
UAB Obesity Training ProgramT32DK062710 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James O Hill, Brooks C Wingo · 2004 to 2026
$5.5M
UAB Statistical Genetics Post-Doctoral Training ProgramT32HL072757 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2003 to 2016
$3.8M
UAB Biostatistics Pre-doctoral Training ProgramT32HL079888 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B, CUTTER, GARY R · 2005 to 2014
$2.3M
Genetic Determinants of Renal Transplant Survival from African American DonorsR01MD009055 · NIMHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DIVERS, JASMIN, FREEDMAN, BARRY IRA · 2014 to 2018
$2.0M
Strengthening Causal Inference in Behavioral Obesity ResearchR25HL124208 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B, BROWN, ANDREW W · 2014 to 2023
$1.8M
The Mathematical Sciences in Obesity ResearchR25DK099080 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON, Andrew W Brown · 2013 to 2026
$1.2M
Using propensity scores for causal inference with covariate measurement errorR01MH099010 · NIMH · JOHNS HOPKINS UNIVERSITY · PI STUART, ELIZABETH A. · 2013 to 2016
$1.1M
Beyond textbook, yet simple, statistical tools for reproducible animal researchR25GM116167 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALLISON, DAVID B, BROWN, ANDREW W · 2015 to 2016
$149k
NHLBI NIH HHS R25 HL124208NHLBI NIH HHS R25HL124208NHLBI NIH HHS T32 HL072757NHLBI NIH HHS T32 HL079888NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30DK056336NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R25 DK099080NIDDK NIH HHS R25DK099080NIDDK NIH HHS T32 DK062710NIDDK NIH HHS T32DK062710NIGMS NIH HHS R25 GM116167NIGMS NIH HHS R25GM116167NIMHD NIH HHS R01 MD009055NIMHD NIH HHS R01MD009055NIMH NIH HHS R01 MH099010NIMH NIH HHS R01MH099010
6 · The paper itself

Abstract

This review identifies 10 common errors and problems in the statistical analysis, design, interpretation, and reporting of obesity research and discuss how they can be avoided. The 10 topics are: 1) misinterpretation of statistical significance, 2) inappropriate testing against baseline values, 3) excessive and undisclosed multiple testing and "P-value hacking," 4) mishandling of clustering in cluster randomized trials, 5) misconceptions about nonparametric tests, 6) mishandling of missing data, 7) miscalculation of effect sizes, 8) ignoring regression to the mean, 9) ignoring confirmation bias, and 10) insufficient statistical reporting. It is hoped that discussion of these errors can improve the quality of obesity research by helping researchers to implement proper statistical practice and to know when to seek the help of a statistician.

Indexed as

BiasData Interpretation, StatisticalObesityBiomedical ResearchHumansResearch Design

Identifiers

PMID27028280
PMCPMC4817356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.