ArticleMolecular microbiology2016
A novel membrane anchor for FtsZ is linked to cell wall hydrolysis in Caulobacter crescentus.
Article in Molecular microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- GTPase activity regulates FtsZ ring positioning inMolecular biology of the cell · 2024Article
- Synthetic control of actin polymerization and symmetry breaking in active protocells.Science advances · 2024Article
- Anchors: A way for FtsZ filaments to stay membrane bound.Molecular microbiology · 2023Review
- FtsA Regulates Z-Ring Morphology and Cell Wall Metabolism in an FtsZ C-Terminal Linker-Dependent Manner in Caulobacter crescentus.Journal of bacteriology · 2020Article
- Non-essentiality of canonical cell division genes in the planctomycete Planctopirus limnophila.Scientific reports · 2020Article
- Agrobacterium tumefaciens divisome proteins regulate the transition from polar growth to cell division.Molecular microbiology · 2019Article
- ZipN is an essential FtsZ membrane tether and contributes to the septal localization of SepJ in the filamentous cyanobacterium Anabaena.Scientific reports · 2019Article
- Direct Interaction between the Two Z Ring Membrane Anchors FtsA and ZipA.Journal of bacteriology · 2019Article
- Amidase activity is essential for medial localization of AmiC in Caulobacter crescentus.Current genetics · 2018Article
- FzlA, an essential regulator of FtsZ filament curvature, controls constriction rate during Caulobacter division.Molecular microbiology · 2018Article
- The intrinsically disordered C-terminal linker of FtsZ regulates protofilament dynamics and superstructureThe Journal of biological chemistry · 2017Article
- FtsEX-mediated regulation of the final stages of cell division reveals morphogenetic plasticity in Caulobacter crescentus.PLoS genetics · 2017Article
- Shapeshifting to Survive: Shape Determination and Regulation in Caulobacter crescentus.Trends in microbiology · 2017Review
- Assembly and activation of the Escherichia coli divisome.Molecular microbiology · 2017Review
- A New Essential Cell Division Protein in Caulobacter crescentus.Journal of bacteriology · 2017Article
- Erin Goley: Catching the bug for studying the cytoskeleton.The Journal of cell biology · 2017Article
- Determinants of Bacterial Morphology: From Fundamentals to Possibilities for Antimicrobial Targeting.Frontiers in microbiology · 2017Review
- An intracellular compass spatially coordinates cell cycle modules in Caulobacter crescentus.Current opinion in microbiology · 2016Review
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Authors and funding
4 authors.
Funding
Abstract
In most bacteria, the tubulin-like GTPase FtsZ forms an annulus at midcell (the Z-ring) which recruits the division machinery and regulates cell wall remodeling. Although both activities require membrane attachment of FtsZ, few membrane anchors have been characterized. FtsA is considered to be the primary membrane tether for FtsZ in bacteria, however in Caulobacter crescentus, FtsA arrives at midcell after stable Z-ring assembly and early FtsZ-directed cell wall synthesis. We hypothesized that additional proteins tether FtsZ to the membrane and demonstrate that in C. crescentus, FzlC is one such membrane anchor. FzlC associates with membranes directly in vivo and in vitro and recruits FtsZ to membranes in vitro. As for most known membrane anchors, the C-terminal peptide of FtsZ is required for its recruitment to membranes by FzlC in vitro and midcell recruitment of FzlC in cells. In vivo, overproduction of FzlC causes cytokinesis defects whereas deletion of fzlC causes synthetic defects with dipM, ftsE and amiC mutants, implicating FzlC in cell wall hydrolysis. Our characterization of FzlC as a novel membrane anchor for FtsZ expands our understanding of FtsZ regulators and establishes a role for membrane-anchored FtsZ in the regulation of cell wall hydrolysis.
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