ReviewAnnals of the American Thoracic Society2016
Allergen-Specific CD4(+) T Cells in Human Asthma.
Review in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis.Nature communications · 2020Pooled it
- Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content.The Journal of allergy and clinical immunology · 2025Trial
- Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.Science advances · 2026Article
- Correlation between systemic allergen desensitisation and long-term asthma protection in mice following intravenous administration of the live tuberculosis vaccine MTBVAC.EBioMedicine · 2024Article
- Large airway T cells in adults with former bronchopulmonary dysplasia.Respiratory research · 2024Article
- Effects of a Peptide Derived from the Primary Sequence of a Kallikrein Inhibitor Isolated fromInternational journal of molecular sciences · 2023Article
- PersistingFrontiers in cellular and infection microbiology · 2023Article
- Article
- Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4The Journal of international medical research · 2022Article
- The extrinsic factors important to the homeostasis of allergen-specific memory CD4 T cells.Frontiers in immunology · 2022Review
- Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children.Clinical and translational allergy · 2021Article
- Reduced JKAP correlates with advanced disease features, inflammation, as well as increased exacerbation risk and severity in asthmatic children.Irish journal of medical science · 2021Article
- Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.BMC pulmonary medicine · 2021Article
- Plasma EVs Display Antigen-Presenting Characteristics in Patients With Allergic Rhinitis and Promote Differentiation of Th2 Cells.Frontiers in immunology · 2021Article
- The Role of Fucoidans Isolated from the Sporophylls ofMolecules (Basel, Switzerland) · 2020Article
- Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children.The Journal of allergy and clinical immunology · 2020Article
- Role of Autophagy in Lung Inflammation.Frontiers in immunology · 2020Review
- Understanding the Interplay Between Health Disparities and Epigenomics.Frontiers in genetics · 2020Review
- Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation.Journal of leukocyte biology · 2019Article
- Associations between Maternal Tobacco Smoke Exposure and the Cord BloodEnvironmental health perspectives · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In allergic asthma, aeroallergen exposure of sensitized individuals mobilizes robust innate and adaptive airway immune responses, stimulating eosinophilic airway inflammation and the activation and infiltration of allergen-specific CD4(+) T cells into the airways. Allergen-specific CD4(+) T cells are thought to be central players in the asthmatic response as they specifically recognize the allergen and initiate and orchestrate the asthmatic inflammatory response. In this article, we briefly review the role of allergen-specific CD4(+) T cells in the pathogenesis of human allergic airway inflammation in allergic individuals, discuss the use of allergen-major histocompatibility complex class II tetramers to characterize allergen-specific CD4(+) T cells, and highlight current gaps in knowledge and directions for future research pertaining to the role of allergen-specific CD4(+) T cells in human asthma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.