Trial reportPloS one2016
Characterization and Correction of Geometric Distortions in 814 Diffusion Weighted Images.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Pooled it
- Longitudinal assessment of diffusion-weighted imaging during magnetic resonance-guided radiotherapy in head and neck cancer.Radiation oncology (London, England) · 2025Trial
- Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults.Alcohol, clinical & experimental research · 2023Trial
- Modulation of amygdala activity for emotional faces due to botulinum toxin type A injections that prevent frowning.Scientific reports · 2023Trial
- Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.Nature medicine · 2022Trial
- Correlation of Preoperative Diffusion-weighted Magnetic Resonance Imaging-based Virtual Elastography with Intraoperative Quantitative Tumor Stiffness in Meningiomas.Neurologia medico-chirurgica · 2026Article
- Uncovering Individual Language Vulnerability in Epilepsy Through Functional Connectivity Laterality.Clinical neuroradiology · 2026Article
- Article
- Multivariate relationships between social cognitive performance and functional connectivity during task and rest across schizophrenia spectrum disorders and healthy controls.Molecular psychiatry · 2026Article
- Predicting pain location from resting-state brain fMRI.bioRxiv : the preprint server for biology · 2026Article
- Feasibility of Precision Functional Mapping in Youth Multi-Echo fMRI Data.bioRxiv : the preprint server for biology · 2026Article
- Binding items to contexts through conjunctive neural representations with the method of loci.Nature communications · 2026Article
- Distinct representational properties of cues and contexts shape fear and reversal learning.eLife · 2026Article
- Neural Tuning for Ordinal Processing: Convergent Patterns in Human Brains and Artificial Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures.BMC medicine · 2026Article
- Article
- Spatial contexts with reliable neural representations support reinstatement of subsequently placed objects.Nature human behaviour · 2026Article
- Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026Article
- Brain activation for actual and imagined hand movement following bilateral hand transplantation.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Similarity in Early Life Stress Exposure Is Associated With Similarity in Neural Representations in Early Adulthood.Human brain mapping · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionDiffusion Weighted Imaging (DWI), which is based on Echo Planar Imaging (EPI) protocols, is becoming increasingly important for neurosurgical applications. However, its use in this context is limited in part by significant spatial distortion inherent to EPI.
methodWe evaluated an efficient algorithm for EPI distortion correction (EPIC) across 814 DWI scans from 250 brain tumor patients and quantified the magnitude of geometric distortion for whole brain and multiple brain regions.
resultsEvaluation of the algorithm's performance revealed significantly higher mutual information between T1-weighted pre-contrast images and corrected b = 0 images than the uncorrected b = 0 images (p < 0.001). The distortion magnitude across all voxels revealed a median EPI distortion effect of 2.1 mm, ranging from 1.2 mm to 5.9 mm, the 5th and 95th percentile, respectively. Regions adjacent to bone-air interfaces, such as the orbitofrontal cortex, temporal poles, and brain stem, were the regions most severely affected by DWI distortion.
conclusionUsing EPIC to estimate the degree of distortion in 814 DWI brain tumor images enabled the creation of a topographic atlas of DWI distortion across the brain. The degree of displacement of tumors boundaries in uncorrected images is severe but can be corrected for using EPIC. Our results support the use of distortion correction to ensure accurate and careful application of DWI to neurosurgical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.