Observational studyPloS one2016
Streptococcus pyogenes Pneumonia in Adults: Clinical Presentation and Molecular Characterization of Isolates 2006-2015.
Observational study in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- A Phase II Study of Modified FOLFOX6 for Advanced Gastric Cancer Refractory to Standard Therapies.Advances in therapy · 2020Trial
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- Severe invasiveJournal of intensive medicine · 2025Article
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- A fulminant case ofWorld journal of emergency medicine · 2025Article
- Article
- Clinical and molecular epidemiological features of critically ill patients with invasive group A Streptococcus infections: a Belgian multicenter case-series.Annals of intensive care · 2024Article
- Streptococcus pyogenes Pneumonia: A Rare and Severe Presentation in a Patient With Asthma.Cureus · 2023Article
- Group A Streptococcus Pneumonia in a Previously Healthy Individual: Is It Still a Thing?Cureus · 2023Article
- Article
- Comparing Genomic Characteristics ofAnnals of laboratory medicine · 2022Article
- Time to Blood Culture Positivity: An Independent Predictor of Mortality inOpen forum infectious diseases · 2022Article
- Hemorrhagic pneumonia and upper lobe pulmonary cavitary lesion caused byJournal of community hospital internal medicine perspectives · 2021Article
- Streptococcal toxic shock syndrome in a patient with community-acquired pneumonia. Impact of rapid diagnostics on patient management.Access microbiology · 2020Article
- Sexual dimorphism in bacterial infections.Biology of sex differences · 2018Review
- Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling.PLoS pathogens · 2018Review
- Article
- Bacterial Pneumonia Caused byJournal of clinical medicine research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn the preantibiotic era Streptococcus pyogenes was a common cause of severe pneumonia but currently, except for postinfluenza complications, it is not considered a common cause of community-acquired pneumonia in adults. AIM AND MATERIAL AND
methodsThis study aimed to identify current clinical episodes of S. pyogenes pneumonia, its relationship with influenza virus circulation and the genotypes of the involved isolates during a decade in a Southern European region (Gipuzkoa, northern Spain). Molecular analysis of isolates included emm, multilocus-sequence typing, and superantigen profile determination.
resultsForty episodes were detected (annual incidence 1.1 x 100,000 inhabitants, range 0.29-2.29). Thirty-seven episodes were community-acquired, 21 involved an invasive infection and 10 developed STSS. The associated mortality rate was 20%, with half of the patients dying within 24 hours after admission. Influenza coinfection was confirmed in four patients and suspected in another. The 52.5% of episodes occurred outside the influenza seasonal epidemic. The 67.5% of affected persons were elderly individuals and adults with severe comorbidities, although 13 patients had no comorbidities, 2 of them had a fatal outcome. Eleven clones were identified, the most prevalent being emm1/ST28 (43.6%) causing the most severe cases.
conclusionsS. pyogenes pneumonia had a continuous presence frequently unrelated to influenza infection, being rapidly fatal even in previously healthy individuals.
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