Evidence map›Paper›PMID 27027521›Full record

ArticleNeuromolecular medicine2016

Effects of Anti-NMDA Antibodies on Functional Recovery and Synaptic Rearrangement Following Hemicerebellectomy.

Daniela Laricchiuta, Virve Cavallucci, Debora Cutuli, Paola De Bartolo, Paola Caporali, Francesca Foti, Carsten Finke, Marcello D'Amelio, Mario Manto, Laura Petrosini

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Article in Neuromolecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniela LaricchiutaDepartment of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy. daniela.laricchiuta@uniroma1.it.
Virve CavallucciIRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Debora CutuliDepartment of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy.
Paola De BartoloIRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Paola CaporaliDepartment of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy.
Francesca FotiDepartment of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy.
Carsten FinkeDepartment of Neurology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Marcello D'AmelioIRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, 00143, Rome, Italy.
Mario MantoUnité d'Etude du Mouvement, FNRS Neurologie, ULB Erasme, 808 Route de Lennik, 1070, Brussels, Belgium.
Laura PetrosiniDepartment of Psychology, Faculty of Medicine and Psychology, University "Sapienza" of Rome, via dei Marsi 78, 00185, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The compensation that follows cerebellar lesions is based on synaptic modifications in many cortical and subcortical regions, although its cellular mechanisms are still unclear. Changes in glutamatergic receptor expression may represent the synaptic basis of the compensated state. We analyzed in rats the involvement of glutamatergic system of the cerebello-frontal network in the compensation following a right hemicerebellectomy. We evaluated motor performances, spatial competencies and molecular correlates in compensated hemicerebellectomized rats which in the frontal cortex contralateral to the hemicerebellectomy side received injections of anti-NMDA antibodies from patients affected by anti-NMDA encephalitis. In the compensated hemicerebellectomized rats, the frontal injections of anti-NMDA antibodies elicited a marked decompensation state characterized by slight worsening of the motor symptoms as well as severe impairment of spatial mnesic and procedural performances. Conversely, in the sham-operated group the frontal injections of anti-NMDA antibodies elicited slight motor and spatial impairment. The molecular analyses indicated that cerebellar compensatory processes were related to a relevant rearrangement of glutamatergic synapses (NMDA and AMPA receptors and other glutamatergic components) along the entire cortico-cerebellar network. The long-term maintenance of the rearranged glutamatergic activity plays a crucial role in the maintenance of recovered function.

Indexed as

AnimalsAntibodiesCerebellumEncephalitisHumansN-MethylaspartateRatsReceptors, AMPARecovery of FunctionSynapsesAntibodiesN-MethylaspartateReceptors, AMPAAnti-NMDA encephalitisCerebellar compensationGlutamate receptorsMorris water mazePostural and motor behaviorsRat

Identifiers

PMID27027521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.